Gliomas Clinical Trials

A listing of Gliomas medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 113 clinical trials
Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients With High Grade Gliomas

enroll patients with histologically confirmed high-grade gliomas to evaluate the ability of regadenoson to transiently disrupt a relatively intact blood-brain barrier (BBB). determine the best

vegf
regadenoson
gliosarcoma
oligodendroglioma
malignant glioma
  • 3 views
  • 18 Feb, 2021
  • 9 locations
Immunotherapy for Recurrent Ependymomas in Children Using Tumor Antigen Peptides With Imiquimod

The purpose of this study is to see if vaccination with HLA-A2 restricted peptides, combined with the immunoadjuvant imiquimod is safe and can induce immune responses in children with recurrent ependymomas. Eligible patients are stratied by primary tumor location.

imiquimod
dexamethasone
metastasis
immunohistochemistry
initial diagnosis
  • 10 views
  • 25 Jan, 2021
  • 1 location
LET Optimized IMPT in Treating Pediatric Patients With Ependymoma

This phase I trial studies the side effects of linear energy transfer (LET) optimized image modulated proton therapy (IMPT) in treating pediatric patients with ependymoma. Radiation therapy such as LET optimized IMPT, uses proton beams to kill tumor cells and shrink tumors without damaging surrounding normal tissues.

ependymoma
tumor cells
  • 1 views
  • 31 Jan, 2021
  • 1 location
Pembrolizumab in Treating Younger Patients With Recurrent Progressive or Refractory High-Grade Gliomas Diffuse Intrinsic Pontine Gliomas Hypermutated Brain Tumors Ependymoma or Medulloblastoma

This phase I trial studies the side effects and best dose of pembrolizumab and to see how well it works in treating younger patients with high-grade gliomas (brain tumors that are generally

filgrastim
malignant glioma
primary brain tumors
biological factors
biologic agent
  • 107 views
  • 01 Aug, 2021
  • 11 locations
Sulfasalazine and Stereotactic Radiosurgery for Recurrent Glioblastoma

This study evaluates the safety associated with the addition of sulfasalazine to stereotactic radiosurgery for recurrent glioblastoma. Sulfasalazine is a potential tumor selective radiosensitizer.

gilbert's syndrome
international normalized ratio
platelet count
karnofsky performance status
glioblastoma multiforme
  • 3 views
  • 23 Jan, 2021
  • 1 location
C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)

This study is for patients with high grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG) or medulloblastoma or another rare brain cancer that expresses GD2. Because there is no

cyclophosphamide
platelet count
malignant glioma
gene transfer
tumor cells
  • 1 views
  • 11 Apr, 2021
  • 1 location
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

This phase I trial studies the side effects and best dose of BGB-290 and temozolomide in treating adolescents and young adults with IDH1/2-mutant grade I-IV glioma that is newly diagnosed or has

malignant glioma
epilepsy
biological factors
progressive disease
biologic agent
  • 24 views
  • 04 Jul, 2021
  • 20 locations
Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)

The standard of care for children with DIPG includes focal radiotherapy (RT) but outcomes have remained dismal despite this treatment. The addition of oral Temozolomide (TMZ) concurrently with RT followed by monthly TMZ was also found to be safe but ineffective. Recent studies in adults have shown that certain types …

  • 15 views
  • 19 Jul, 2021
  • 2 locations
Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors

This is a safety (Phase 1) trial using mebendazole for recurrent pediatric brain cancers that include medulloblastoma and high grade glioma, that are no longing responding to standard therapies

malignant glioma
cancer
medulloblastoma
treatment regimen
initial diagnosis
  • 202 views
  • 26 Jan, 2021
  • 2 locations
Nedisertib and Radiation Therapy Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma

This phase I trial investigates the side effects and best dose of nedisertib, and to see how well it works in combination with radiation therapy in treating patients with newly diagnosed MGMT unmethylated glioblastoma or gliosarcoma. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Nedisertib …

MRI
gliosarcoma
tumor cells
karnofsky performance status
dexamethasone
  • 0 views
  • 10 Jun, 2021