Gliomas Clinical Trials

A listing of Gliomas medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 112 clinical trials
STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the Brain

This phase I trial studies the side effects and best dose of STAT3 inhibitor WP1066 in treating patients with malignant glioma that has come back or melanoma that has spread to the brain and is

antiepileptic
metastatic melanoma
BRAF
glioblastoma multiforme
measurable disease
  • 56 views
  • 23 Jan, 2021
  • 1 location
Trial of Panobinostat in Children With Diffuse Intrinsic Pontine Glioma

This phase I trial studies the side effects and best dose of panobinostat in treating younger patients with diffuse intrinsic pontine glioma (DIPG). Panobinostat may stop the growth of tumor

potassium
monoclonal antibodies
calcium
corticosteroids
nitrosoureas
  • 27 views
  • 26 Mar, 2021
  • 10 locations
Hyperpolarized 13C-pyruvate Metabolic MRI With Infiltrating Gliomas

hyperpolarized metabolic MRI to diagnose intermediate to patients with infiltrating gliomas and examine the added utility of metabolic MRI over standard MRI imaging The FDA is allowing the use of

  • 0 views
  • 04 Mar, 2021
  • 1 location
CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas

nanoparticle formulation) and Gadolinium that can be given safely in children with newly diagnosed diffuse midline gliomas. All patients enrolled in the study will receive infusion of MTX110 and Gadolinium

anesthesia
epilepsy
seizures
neutrophil count
anticonvulsants
  • 1 views
  • 28 Jan, 2021
Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma

Diffuse intrinsic pontine gliomas (DIPGs), which diffusely occupy the pons of brainstem, are the deadliest primary brain cancer in children. Biopsy for pathology plus radiotherapy remains the

  • 0 views
  • 14 Jul, 2021
  • 1 location
Study of the Effect NT-I7 on CD4 Counts in Patients With High Grade Gliomas

The purpose of this study is to determine the maximum tolerated dose (MTD) and select optimal biological doses (OBD) of the study drug NT-I7 in High Grade Glioma patients with severe lymphopenia

aptt
karnofsky performance status
biologic agent
interleukins
neutrophil count
  • 0 views
  • 27 Apr, 2021
  • 12 locations
ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas

this research study is evaluating the highest dose of ASTX727 that can be administered safely to recurrent/progressive non-enhancing IDH mutant gliomas patients.

  • 3 views
  • 25 Jan, 2021
Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma

The purpose of this study is to test how well the drug works, safety and tolerability of an investigational drug called Ruxolitinib in gliomas and glioblastomas, when combined with standard

karnofsky performance status
malignant brain tumor
temozolomide
oligodendroglioma, anaplastic
glioblastoma multiforme
  • 31 views
  • 12 Jun, 2021
  • 2 locations
Hydroxy-urea and Temozolomide in Patients With a Recurrent Malignant Brain Tumor (Glioblastoma)

Background Currently, no standard treatment exists for patients with recurrent glioblastoma multiforme (rGBM) and used 2nd line treatments have low (up to max. 20%) response rates and very modest response duration (months). The median overall survival for GBM patients is 12-14 months from the time of diagnosis; therefore the development …

karnofsky performance status
malignant brain tumor
temozolomide
isotretinoin
tamoxifen
  • 147 views
  • 25 Jan, 2021
  • 1 location
Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

receptor (CAR) and EGFRt. CAR T cells are delivered via an indwelling catheter into the tumor resection cavity or ventricular system in children and young adults with diffuse intrinsic pontine glioma (DIPG

cns disease
cns tumor
tumor cells
MRI
cns neoplasm
  • 8 views
  • 22 Mar, 2021
  • 1 location