Gliomas Clinical Trials

A listing of Gliomas medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 78 clinical trials
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

untreated low-grade glioma (LGG) that does not have a genetic abnormality called BRAFV600E mutation and is not associated with systemic neurofibromatosis type 1. Selumetinib works by blocking some of the

giant cell astrocytoma
ejection fraction
seizure
neutrophil count
tumor cells
  • 14 views
  • 24 Sep, 2021
  • 53 locations
Olaparib in Treating Patients With Advanced Glioma Cholangiocarcinoma or Solid Tumors With IDH1 or IDH2 Mutations

This phase II trial studies how well olaparib works in treating patients with glioma, cholangiocarcinoma, or solid tumors with IDH1 or IDH2 mutations that have spread to other places in the body

chemoradiotherapy
neutrophil count
olaparib
tumor cells
serum pregnancy test
  • 110 views
  • 17 Sep, 2021
  • 25 locations
Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

grade II or III glioma. Proton beam radiation therapy uses tiny charged particles to deliver radiation directly to the tumor and may cause less damage to normal tissue. Intensity-modulated or photon

astrocytoma
step 2
neutrophil count
karnofsky performance status
oligoastrocytoma
  • 38 views
  • 23 Sep, 2021
  • 14 locations
Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

Background Glioblastoma is a type of brain cancer. Treatments include radiation, chemotherapy, and surgery. But survival rates are poor. Researchers think that the drug selinexor, when combined with chemotherapy and radiation, might help. Objective To learn the highest dose of selinexor that people with brain cancer can tolerate when given …

brain tumor
ct scan
cancer
therapeutic agent
neutrophil count
  • 43 views
  • 12 Sep, 2021
  • 1 location
Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

Background A glioblastoma is a tumor in the brain. It is treated with surgery, chemotherapy and radiation therapy. However, most people s tumors come back after therapy. When the tumor grows back, surgery or chemotherapy may not be possible or may no longer work. Repeat radiation therapy or re-irradiation, is …

combined modality therapy
bevacizumab
glioblastoma multiforme
gliosarcoma
recurrent glioblastoma
  • 41 views
  • 22 Sep, 2021
  • 1 location
HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors

This is a prospective randomized clinical trial, to determine whether dose-intensive tandem Consolidation, in a randomized comparison with single cycle Consolidation, provides an event-free survival (EFS) and overall survival (OS). The study population will be high-risk patients (non-Wnt and non-Shh sub-groups) with medulloblastoma, and for all patients with central nervous …

central nervous system tumor
neutrophil count
platelet count
vincristine
MRI
  • 197 views
  • 24 Sep, 2021
  • 62 locations
BGB-290 and Temozolomide in Treating Patients With Recurrent Gliomas With IDH1/2 Mutations

This phase I/II trial studies the side effects and how well BGB-290 and temozolomide work in treating patients with gliomas (brain tumors) with IDH1/2 mutations that have come back. BGB-290 may

procarbazine
neutrophil count
tumor cells
serum pregnancy test
therapeutic conventional surgery
  • 1 views
  • 17 Sep, 2021
  • 17 locations
Serial MR Imaging and MR Spectroscopic Imaging for the Characterization of Lower Grade Glioma

This trial studies how well serial magnetic resonance (MR) imaging and MR spectroscopic imaging work in characterizing lower grade glioma. Diagnostic procedures, such as MR imaging and MR

  • 0 views
  • 22 Sep, 2021
  • 1 location
Protein Phosphatase 2A Inhibitor in Recurrent Glioblastoma

Background The brain is separated from the rest of the blood stream by the blood-brain barrier. This is like a filter that protects the brain. But is also a challenge when medicines need to get into the brain. Researchers want to give the new drug LB100 to people before brain …

astrocytoma
renal function test
brain tumor
glioblastoma multiforme
recurrent disease
  • 22 views
  • 12 Sep, 2021
  • 1 location
Study of Re-irradiation at Relapse Versus RT and Multiple Elective rt Courses

Prospective, non-blinded, randomised two cohorts study on the efficacy of two different radiotherapy schedule for DIPG by using the same concomitant and post-radiotherapy systemic treatment.

re-irradiation
nimotuzumab
  • 1 views
  • 12 Sep, 2021
  • 1 location