Gliomas Clinical Trials

A listing of Gliomas medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 74 clinical trials
Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

This phase II trial studies how well the combination of dabrafenib and trametinib works after radiation therapy in children and young adults with high grade glioma who have a genetic change

MRI
astrocytoma
epilepsy
glioblastoma multiforme
ganglioglioma
  • 129 views
  • 27 Sep, 2021
  • 57 locations
Feasibility Trial of Optune for Children With Recurrent or Progressive Supratentorial High-Grade Glioma and Ependymoma

This feasibility trial studies how well the Optune device works in treating younger patients with recurrent/refractory/progressive supratentorial malignant glioma and ependymoma. The TTFields

biologic agent
corticosteroids
craniospinal irradiation
nitrosoureas
biological factors
  • 6 views
  • 24 Sep, 2021
  • 9 locations
UNIty-Based MR-Linac Guided AdapTive RadiothErapy for High GraDe Glioma: A Phase 2 Trial

Glioblastoma (GBM) is a high grade glioma (brain tumor) that is treated with surgery or biopsy followed by radiotherapy (RT) given daily over 3 or 6 weeks with or without an oral chemotherapy

MRI
brain tumor
residual tumor
cancer
malignant glioma
  • 0 views
  • 27 Sep, 2021
  • 1 location
Pembrolizumab (MK-3475) in Patients With Recurrent Malignant Glioma With a Hypermutator Phenotype

The purpose of this study is to test if the study drug called pembrolizumab could control the growth or shrink the cancer but it could also cause side effects. Researchers hope to learn if the study drug will shrink the cancer by half, or prevent it from growing for at …

MRI
astrocytoma
cancer
neutrophil count
blood transfusion
  • 0 views
  • 26 Sep, 2021
  • 16 locations
Hyperpolarized Imaging in Diagnosing Participants With Glioma

This pilot trial studies the side effects of hyperpolarized carbon C 13 pyruvate magnetic resonance imaging (MRI) in diagnosing participants with glioma. Diagnostic procedures, such as

MRI
renal function
karnofsky performance status
temozolomide
cancer
  • 3 views
  • 26 Sep, 2021
  • 1 location
Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma

, whole-exome sequencing (WES), targeted panel profile (UCSF 500 gene panel), and RNA-Seq. The current study will test the efficacy of such an approach in children with High-grade gliomas HGG

MRI
epilepsy
dipg
diffuse intrinsic pontine glioma
malignant glioma
  • 24 views
  • 26 Sep, 2021
  • 14 locations
Study of Letrozole in Recurrent Gliomas

The purpose of this study is to determine the ability of letrozole to penetrate the blood brain barrier and concentrate in gliomas.

  • 12 views
  • 22 Sep, 2021
  • 1 location
INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas

This is a multicenter phase 1 trial of INCB7839 for children with recurrent or progressive high-grade gliomas, including, but not limited to, diffuse intrinsic pontine glioma (DIPG) and other

MRI
astrocytoma
epilepsy
glioblastoma multiforme
erythropoietin
  • 0 views
  • 26 Sep, 2021
  • 11 locations
ONC201 in Adults With Recurrent H3 K27M-mutant Glioma

The primary objective of this phase II trial is to determine the efficacy and safety of ONC201, an oral small molecule imipridone DRD2 antagonist, in adult subjects with recurrent high-grade

brain mri
bilateral tubal ligation
MRI
dna sequencing
bevacizumab
  • 24 views
  • 18 Sep, 2021
  • 9 locations
Trial of Panobinostat in Children With Diffuse Intrinsic Pontine Glioma

This phase I trial studies the side effects and best dose of panobinostat in treating younger patients with diffuse intrinsic pontine glioma (DIPG). Panobinostat may stop the growth of tumor

panobinostat
corticosteroids
calcium
potassium
erythropoietin
  • 27 views
  • 26 Sep, 2021
  • 10 locations