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Headaches Clinical Trials

A listing of Headaches medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (189) clinical trials

This purpose of this study is to evaluate the safety and tolerability of 52 weeks of treatment with an investigational study medication, atogepant for the prevention of migraine headaches.  Study participation may last up to 60 weeks and include up to 16 visits to the research center. After an initial ...

Phase N/A

The Effects of Caffeine Withdrawal on Migraine

The actions of caffeine as an antagonist of adenosine receptors have been extensively studied, and there is no doubt that both daily and sporadic dietary consumption of caffeine has substantial biological effects on the nervous system. The current opinion is that caffeine both can cure and trigger headaches. Caffeine is ...


(Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist

Eligible patients for migraine surgery will be injected unilaterally with Botox prior to surgery. The effects of Botox on tissues will be evaluated.


Post-dural Puncture Headache - Needles and Biomarkers in CSF

Subjects are patients scheduled for a diagnostic LP as part of their routine clinical management at the department of Neurology, Nordland Hospital in Bod, Norway. Selection is based on the inclusion and exclusion criteria listed beneath, independent of the primary clinical indication for the procedure. Informed consenting patients will be ...

Phase N/A

Feasibility of Using a Mobile Device Controlled Micro-pressure Pulse Insufflator for Acute Migraine Relief

After signing the consent form and being enrolled in the study, the subject will be asked to answer an enrollment questionnaire on the general characteristics of the migraine attacks he or she is suffering. Then, the subject will be instructed to call 1-800 number to notify the clinic that they ...

Phase N/A

Specific Neck Rehabilitation for Unilateral Neck Related Headache and Structural Changes in the Brain

The project includes two parts: Part 1: With a longitudinal semicross-over randomized control design (n: 42) the investigators will compare the clinical efficacy of a 6 month specific neck rehabilitation with standard primary health care on patients with cervicogenic headache. The patients will either receive a specific neck rehabilitation program, ...

Phase N/A

Intranasal Ketorolac Versus Intravenous Ketorolac for Treatment of Migraine Headaches in Children

Primary Aim: Determine whether intranasal (IN) ketorolac is non-inferior to intravenous (IV) ketorolac for reducing pain in children with acute migraine headaches. We hypothesize that IN ketorolac is non-inferior to IV ketorolac in reducing acute migraine headache pain by a minimum clinically significant difference within 60 minutes of administration. Secondary ...


Long-term Safety and Tolerability of Subcutaneous Administration of TEV-48125 for the Preventive Treatment of Migraine

To evaluate the long-term safety and tolerability of subcutaneous (SC) administration of TEV-48125 (at 225 mg once monthly [except for a loading dose of 675 mg for CM patients] or at 675 mg every 3 months) for the preventive treatment of Chronic Migraine and Episodic Migraine patients


Psilocybin for the Treatment of Migraine Headache

The purpose of this study is to investigate the effects of oral psilocybin in migraine headache. Subjects will each receive a dose of placebo and a dose of psilocybin approximately 14 days apart. Subjects will be randomized to the order of treatment and they will be randomized to receive either ...


Continuous Positive Airway Pressure as a Potential New Treatment for Cluster Headache

This is a single center study carried out in collaboration between the neurological, neurophysiological and thoracic departments at St. Olavs Hospital in Trondheim. Participants will keep sleep and headache diaries in a baseline period of 4 weeks, then receive treatment (CPAP or sham-CPAP at nighttime) during 8 weeks, have a ...

Phase N/A