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Cardiomyopathy Clinical Trials

A listing of Cardiomyopathy medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (112) clinical trials

Predictive Factors and Consequences of Myocardial Fibrosis in Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a rare genetic disease (1), whose phenotypic expression is found in less than 1/1000 people, mainly linked to a mutation of a protein of the sarcomere (14 genes and 400 mutations identified nowadays). HCM occurs in about 50% of cases in young adults under the age ...

Phase N/A

Anti-Angiotensin-Receptor 1 (ATR1)- Anti-Endothelin-Receptor A (ETRA)-Antibodies and T Cells in Cardiomyopathy

AIM OF THE STUDY 1.1. Background Progressive interstitial fibrosis parallels pathological remodeling in the failing heart. This is particularly the case in patients with post-inflammatory dilated cardiomyopathy, but is also observed in ischemic and hypertensive heart disease. Both, Angiotensin II (AngII) and Endothelin-1 (ET1) induce the formation of the profibrotic ...

Phase N/A

Prediction of Sudden Cardiac Death in Dilated Cardiomyopathy

Prophylactic ICD implantation was recently found to be non-beneficial over usual clinical care in non-ischemic systolic heart failure (LVEF35%) and 60-70% percent of SCD cases even occur in individuals with LEVF>35%. A growing evidence, that emphasizes the urgent need to improve the prediction of sudden cardiac death (SCD) in dilated ...

Phase N/A

Exercise in Genetic Cardiovascular Conditions

Yale is the central site for this multicenter study. Patients with HCM and LQTS will be recruited via high-volume HCM and LQTS sites, patient-groups, and websites. Information about exercise participation will be acquired via interview and online instruments at enrollment and every six months for three years. Quality of Life ...

Phase N/A

Double Push Acoustic Radiation Force (DP ARF) Ultrasound for Monitoring Degeneration in Duchenne Muscular Dystrophy

Double Push Acoustic Radiation Force (DP ARF) imaging will be performed in 3 cohorts of up to 10 boys with DMD and in age-matched boys with no known neuromuscular disorders. The first DMD cohort will enroll at age 5-6, the second at age 7-8, and the third at age 9-10. ...

Phase N/A

German Centre for Cardiovascular Research Cardiomyopathy Register

The following basic research projects, called modules, will be tied to and rely on the recruitment of CMP patients and the infrastructure provided by TORCH: Well phenotyped patients will be the starting point for comprehensive next-generation genotyping, leading to advanced estimates of genotype-phenotype relationship and its clinical impact. Functional analysis ...

Phase N/A

Biomarkers of Inherited Cardiovascular Conditions

In young adults and children inherited cardiac conditions (ICCs) that affect cardiac structure and electrical activity, account for most cases of sudden cardiac death. Of the ICCs, SCD due to Brugada Syndrome is particularly prevalent in SE Asia where it causes early loss of life in young men. While there ...

Phase N/A

Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases

Molecular genetic screening in patients with: - supraventricular - ventricular arrhythmia - syncopes of unknown origin and/or suspicion of an arrhythmogenic origin - family members of patients with sudden cardiac death and aborted sudden cardiac death Examination of patients includes routine testing like electrocardiogram (ECG), sequential ECGs, exercise testing, invasive ...

Phase N/A

The Genetics of Dilated Cardiomyopathy: A Quebec-Based Study

Dilated cardiomyopathy (DCM) affects about 200,000 Canadians. Eighty percent of these cases are of unclear cause, often occuring in families. We believe that mutations in specific already-identified genes contribute to DCM in Quebec and that certain mutations may account for a significant proportion of cases due to the well-documented "founder ...

Phase N/A

Registry and Survey of Women With Pregnancy Related Cardiomyopathy

The design of our study will utilize web-based recruitment methods with internet-based support groups for PPCM e.g. ( The directors of these websites will facilitate contact between our research staff and the several hundred members of these web sites. An introductory letter will be posted on the website introducing ...

Phase N/A