Neurofibromatosis Clinical Trials

A listing of Neurofibromatosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 57 clinical trials
DPCP to Treat Cutaneous Neurofibromas Associated With NF1

Neurofibromatosis type 1 (NF1) is the most common genetic tumor predisposition syndrome, affecting up to 1 in 2500 individuals. Cutaneous neurofibromas are benign with self-limited growth

  • 0 views
  • 07 Oct, 2022
  • 1 location
Neoadjuvant Nivolumab Plus Ipilimumab for Newly Diagnosed Malignant Peripheral Nerve Sheath Tumor

Neurofibromatosis Type 1 (NF1) and newly diagnosed pre-malignant and malignant peripheral nerve sheath tumors (MPNST) for whom surgery for resection of tumor is indicated.

  • 0 views
  • 10 Jul, 2022
  • 1 location
Auditory Brainstem Implant (ABI) in Children With No Cochleae or Auditory Nerves

This study is a feasibility study of the Nucleus 24 ABI in children without NF2. It will be conducted as a repeated-measures, single subject experiment in order to accommodate the known variability in cochlear implant clinical results. Data obtained in the course of this study will be compared with the …

  • 29 views
  • 08 Apr, 2023
  • 1 location
A Phase I/II, Single-Arm, Open Label Study to Evaluate the Pharmacokinetics, Safety/Tolerability and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With Neurofibromatosis Type 1 (NF1) Related Symptomatic, Inoperable Plexiform Neurofibromas (PN) (SPRINKLE) (SPRINKLE)

This study is designed to define a dosing regimen and assess the pharmacokinetics(PK) and safety of the granule formulation; the study will also include descriptive analyses of exploratory efficacy endpoints. The study will inform the benefit risk profile of the granule formulation in children aged ≥ 1 to < 7 …

  • 0 views
  • 13 Oct, 2022
  • 7 locations
  • 0 views
  • 25 Oct, 2022
  • 26 locations
Pediatric Long-Term Follow-up and Rollover Study

A roll-over study to assess long-term effect in pediatric patients treated with dabrafenib and/or trametinib.

dabrafenib
trametinib
  • 492 views
  • 12 Apr, 2023
  • 42 locations
HL-085 in Adults With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas

This is a Multi-center, Open-label, Single-arm Phase II Study to Evaluate the Efficacy and Safety of HL-085 in the treatment of Adult Participants with Neurofibromatosis Type 1 (NF1) and

nf1 mutation
measurable disease
dysplasia
  • 0 views
  • 28 Apr, 2022
  • 1 location
Photodynamic Therapy for Benign Dermal Neurofibromas- Phase II

The investigators wish to determine the time to disease progression for benign neurofibromas treated with Levulan Kerastick topical photosensitizer and red light photodynamic therapy (PDT) in

tumor growth
  • 79 views
  • 23 Feb, 2022
  • 1 location
Doxycycline Injection of Cutaneous Schwannoma in Neurofibromatosis Type 2

In this research study the investigators want to learn more about an alternate, local treatment for skin schwannomas. Specifically, local doxycycline intra-tumoral injection will be performed as a potential treatment for NF2-related skin schwannomas, ultimately reducing the risks and costs associated with standard surgical removal of such skin tumors if …

  • 0 views
  • 10 Oct, 2022
  • 1 location
A Phase I/II Study of the Cyclin-Dependent Kinase(CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type 1 (NF1) Related Atypical Neurofibromas

Background NF1 is a genetic disease that causes tumors called atypical neurofibromas. These tumors, which arise from nerves, can cause serious medical problems

plexiform neurofibroma
ejection fraction
dysplasia
measurable disease
serum pregnancy test
  • 0 views
  • 21 Oct, 2022
  • 1 location