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Vaccines Clinical Trials

A listing of Vaccines medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found (74) clinical trials

HPV Vaccination in Africa- New Delivery Schedules Alias The HANDS HPV Vaccine Trial

This study is a randomized, open-label, single-centre, phase 3 non-inferiority clinical trial of the Gardasil 9 vaccine. It will be undertaken in three female cohorts (15 to 26 years old; 9 to 14 years-olds and 4 to 8 year-olds). In total 1720 female participants will be recruited in a rural …


Effects of Biktarvy on CFR in Stable HIV Patients

Positron emission tomography (PET) imaging allows precise and reproducible quantification of myocardial blood flow, thereby providing a direct assessment of coronary vascular health. Coronary flow reserve (CFR, calculated as the ratio of peak hyperemic myocardial blood flow over that at rest) is emerging as a powerful quantitative prognostic imaging marker …


Vaccination Against Influenza to Prevent Cardiovascular Events After Acute Coronary Syndromes

Phase III, randomized, controlled, multicenter, open label, superiority, 1:1 allocation, blind assessment of clinical outcomes and intention-to-treat analysis clinical trial to determine whether increased doses of influenza vaccine in the hospital phase, when compared to usual dose vaccination (30 days hospital discharge), reduce the risk of major cardiovascular events (cardiovascular …


Improving Maternal heAlth by Reducing Malaria in African HIV Women

Background Intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) is recommended for malaria prevention in HIV-uninfected women but it is contraindicated in those HIV-infected on cotrimoxazole prophylaxis (CTXp) due to potential adverse effects. A recent trial showed that an effective antimalarial added to CTXp and long-lasting insecticide treated nets …


Effectiveness and Safety of a Heterologous Two-dose Ebola Vaccine in the DRC

Ebola Virus Disease (EVD) is an acute, systemic, febrile syndrome caused by Ebola viruses. EVD has a case fatality ranging from 30% to 90% and spreads by direct contact with body fluids of symptomatic patients. During the 2013-16 Ebola outbreak in Guinea, a Phase 3 cluster-randomised ring-vaccination trial using single-dose …


Long-Term Safety and Antibody Persistence of TDV and Impact of a Booster Dose

The vaccine tested in this study is Takeda's Tetravalent Dengue Vaccine Candidate (TDV). This study will look at the long-term antibody persistence and safety of Takeda's TDV in healthy adolescents and adults and will assess the impact of a booster dose. The study will enroll approximately 600 healthy participants. Participants …


Intradermal Influenza Vaccine With Topical Imiquimod in Elderly and Chronic Illness Patients

This is a prospective; double-blind randomized controlled study performed in the HKWC. Recruited subjects include subjects 50 years and adult subjects 18 years with chronic illness. Eligible subjects will be randomly allocated (3:3:2) into one of the three groups in the first year. Group IQ: topical 5% 250mg imiquimod ointment …


IMVAMUNE Smallpox Vaccine in Adult Healthcare Personnel at Risk for Monkeypox in the Democratic Republic of the Congo

Orthopoxvirus infections produce antibody responses that are cross-protective against other viruses within the genus. It is this property of orthopoxviruses that allows a vaccine for vaccinia virus against smallpox to be used to provide protection against monkeypox. Studies performed during and in the immediate aftermath of smallpox eradication demonstrated that …


Optimizing Smoking Cessation for People With HIV/AIDS Who Smoke

The investigators propose a factorial design strategy to evaluate the effects, individually and in combination, of the most promising pharmaco- and behavioral cessation therapies available for PLWH according to the review of the extant literature for HIV-infected and general population smokers. The sizable cohort and prospective design will also permit …