Post-Partum Depression Clinical Trials

The purpose of this study is to test an investigational drug called SAGE-547 (Allopregnolone) to determine if it is safe and has any effect on moderate and/or severe postpartum depression. An investigational drug is one that is not approved by the United States Food and Drug Administration (FDA).

To determine if SAGE-547 Injection infused intravenously for 60 hours reduces depressive symptoms in subjects with postpartum depression (PPD) compared to placebo injection

The purpose of the study is to examine how mother's mental health experiences might influence brain function in response to her infant and how this might be related to the parent-infant relationship. There will be 2 study visits over 7 to 10 days. The first visit is 3 to 4 ...

The primary objective of the study is to evaluate the effects of brexanolone on depressive symptoms when administered to adolescent female subjects diagnosed with post-partum depression (PPD).  

Disturbances in mother-infant relationship in depressed mothers negatively influence the child's development. There are a number of efficient treatments for postnatal depression including antidepressant medication, psychotherapy and psychosocial interventions. Tele-health and mobile health is a novel and emerging field in psychiatric and psychological care and treatment of mental health difficulties, ...

This is an open-label study designed to investigate the feasibility and tolerability of a novel TMS treatment protocol to treat depression in women with post-partum depression. It is known that TMS can effectively treat depression. The FDA approved protocol lasts 6 weeks and is not feasible for many women with ...

Perinatal depression is a common and serious mood disorder that increases morbidity and mortality in new mothers and results in poor infant/child outcomes. Current therapies often fail to produce recovery or are poorly tolerated and many pregnant women seek non-pharmacologic therapy or forgo treatment when non-pharmacologic options are not available. ...

To address the life course needs of depressed mothers and their infants, brief, accessible, and integrated interventions that target both maternal depression and specific nurturing parent behaviors demonstrated to improve infant social-emotional communication outcomes are needed. In prior programmatic research, two separate web-based, remote coaching interventions for: (a) parent nurturing ...

Despite the high prevalence of maternal depression in Pakistan, research on psychosocial interventions is limited. We will test the effectiveness of a telephone based intervention program called Learning through Play plus Interpersonal Psychotherapy (LTP Plus) that can be used by non-specialists, including trained graduates, mothers and lay health workers with ...

Enhancements to Mothers and Babies are warranted to address the mental health of both parents, via the home visitation service delivery model where many of the most at-risk families enter into provider-client relationships during their child's infancy and early childhood. Previous postpartum depression preventive interventionsincluding MBhave neglected to intervene with ...