Emotional Processing Clinical Trials

In a double-blind, randomized, placebo-controlled, between-subject design healthy volunteers will receive either oxytocin or placebo nasal spray (40IU in 10 puffs). Subjects will come to the experiment in pairs (two friends of the same sex). 45 min after drug administration, the two subjects will simultaneously undergo a social reward task ...

Emotional processing deficits have a significant negative impact on the lives of persons with TBI. There is emerging research indicating that, in addition to cognitive and behavioral impairments, social and emotional difficulties following TBI are common and are related to significant problems in social relationships, poor social participation, impaired empathy, ...

This study will test the effectiveness of an emotional processing intervention in individuals with MS in a double blind placebo controlled randomized clinical trial RCT). We will utilize an intervention which has been successfully used in other populations, including Schizophrenia and Traumatic Brain Injury. Our pilot data shows that this ...

BACKGROUND Mindfulness is typically defined as a present-centered non-judgmental awareness (Kabat-Zinn, 1990). In the last 30 years mindfulness-based approaches have been extensively used for a variety of mental disorders, including affective disorders characterized by emotion dysregulation (Khoury et al., 2013). Mindfulness-based cognitive therapy (MBCT) includes meditation techniques to help participants ...

Anhedonia (the lack of pleasure in normally pleasurable things) is a common symptom of major depressive disorder (MDD), and it may impact how patients with depression experience reward. Understanding how anhedonia is related to the experience of reward may help improve how depression is treated. Computer tasks can be used ...

Epilepsy is a relatively common neurological disorder diagnosed when individuals suffer from repeated unprovoked seizures. Estimates of prevalence rates vary, but it is generally considered to be about 1% of the U.S. population. Of the patients diagnosed with epilepsy, about 60-70 percent are diagnosed with complex-partial seizures, and of these ...

Methods: 40 subjects with major depression (20 active treatment and 20 placebo) will receive ten 30-minutes sessions of active two milliamps or sham tDCS (anode over left dorsolateral prefrontal cortex and cathode over right dorsolateral prefrontal cortex), twice a day for 5 consecutive days. Psychometric assessment of depression (MADRS,Beck Depression ...

Background The dopamine receptor agonist pramipexole has recently been suggested as a potential novel antidepressant drug. While preliminary clinical data hint at its efficacy in treating depressive symptoms, our current understanding of its impact on neurocognitive processes is relatively limited. This is in part because, so far, mechanistic studies have ...

Background and objective: Previous research indicates that various physiological treatments for depression (especially antidepressant drugs) can induce positive biases in emotional information processing and it has been suggested that this might be a crucial common mechanism through which they exert their clinical effects. This study aims to investigate whether similar ...

Main goals This research project generally aims to refine our understanding of the similarities and distinctions between bipolar and schizophrenic patients in emotional information processing. Specifically, these are: better understand what level of emotional information processing both conditions differ or are comparable and in what direction assess specifically in both ...