Colon Cancer Clinical Trials

A listing of Colon Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 197 clinical trials
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

This is a Phase I dose-escalation and dose-expansion study that will evaluate the safety, pharmacokinetics (PK), and preliminary activity of GDC-6036 in patients with advanced or metastatic solid tumors with a KRAS G12C mutation.

KRAS
solid tumour
ki-ras
cetuximab
atezolizumab
  • 98 views
  • 19 Sep, 2023
  • 67 locations
Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation (KontRASt-01)

This is a phase Ib/II open label study. The escalation part will characterize the safety and tolerability of JDQ443 single agent and JDQ443 in combination with the other study treatments (TNO155 and tislelizumab) in advanced solid tumor patients. After the determination of the maximum tolerated dose / recommended dose for …

KRAS
solid tumor
measurable disease
  • 8 views
  • 19 Sep, 2023
  • 34 locations
Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors (innovaTV 207)

This trial will study tisotumab vedotin to find out whether it is an effective treatment for certain solid tumors and what side effects (unwanted effects) may occur. There are seven parts to this study. In Part A, the treatment will be given to participants every 3 weeks (3-week cycles). In …

solid tumour
fluoropyrimidine
measurable disease
systemic therapy
adenocarcinoma
  • 247 views
  • 29 Sep, 2023
  • 32 locations
The Cancer of the Pancreas Screening-5 CAPS5)Study (CAPS5)

Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.

synthetic secretin
secretin
BRCA2
palb2
cancer
  • 185 views
  • 04 Oct, 2022
  • 8 locations
GEN1042 Safety Trial and Anti-tumor Activity in Subjects With Malignant Solid Tumors

To evaluate the safety and anti-tumor activity of GEN1042 in patients with metastatic or locally advanced solid tumors.

solid tumour
metastatic melanoma
measurable disease
systemic therapy
carboplatin
  • 32 views
  • 11 Sep, 2023
  • 42 locations
Randomised Study Evaluating Adjuvant Chemotherapy After Resection of Stage III Colonic Adenocarcinoma in Patients of 70 and Over (ADAGE)

chemotherapy has demonstrated a benefit on disease-free survival and overall survival after a stage III colon cancer resection. Nevertheless adjuvant chemotherapy is poorly used in elderly patients. Prognostic

cancer
fluoropyrimidine
capecitabine
stage iii colon cancer
colon cancer
  • 31 views
  • 26 Aug, 2023
  • 137 locations
A Study of SGN-STNV in Advanced Solid Tumors

This trial will look at a drug called SGN-STNV to find out whether it is safe for patients with solid tumors. It will study SGN-STNV to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study how well …

human chorionic gonadotropin
ovarian cancer
measurable disease
adenocarcinoma
erbb2
  • 0 views
  • 18 Sep, 2023
  • 18 locations
Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)

In this study, participants with multiple types of advanced (unresectable and/or metastatic) solid tumors who have progressed on standard of care therapy will be treated with pembrolizumab (MK-3475).

thyroid carcinoma
solid neoplasm
measurable disease
systemic therapy
solid tumor
  • 20 views
  • 06 Apr, 2023
  • 22 locations
Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"

The main goal of this phase of the study is to determine if objectively assessed Physical Activity (PA) levels in advanced-cancer patients are associated with health care provider (HCP)-assessed ECOG performance status and overall survival. The purpose is to advance the evidence-base for incorporating objective assessment of Physical Activity (PA) …

cyst
adenocarcinoma
cancer diagnosis
primary cancer
advanced cancer
  • 43 views
  • 20 Aug, 2023
  • 1 location
Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps (FORTE)

This trial examines colorectal cancer incidence in participants with 1 to 2 non-advanced adenomas randomized to surveillance colonoscopy at 10 years compared to participants randomized to surveillance colonoscopy at 5 and 10 years.

  • 20 views
  • 18 Aug, 2023
  • 157 locations