Colon Cancer Clinical Trials

A listing of Colon Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 168 clinical trials
Pooled Mutant KRAS-Targeted Long Peptide Vaccine Combined With Nivolumab and Ipilimumab for Patients With Resected MMR-p Colorectal and Pancreatic Cancer

Phase 1 study for patients with resected PDAC after neoadjuvant and/ or adjuvant chemotherapy and/or radiation, as well as patients with metastatic MSS CRC who have progressed on 2 or more lines of chemotherapy, to evaluate safety and the immune response to pooled mutant-KRAS peptide vaccine (KRAS peptide vaccine) with …

pdac
ipilimumab
immunostimulant
irinotecan
KRAS
  • 0 views
  • 04 Oct, 2022
  • 1 location
Trametinib + HDM201 in CRC Patients With RAS/RAF Mutant and TP53 Wild-type Advanced/Metastatic Colorectal Cancer Mutant and TP53 Wild-type (TRAHD)

vivo, in mice harboring human RKO colon tumor xenografts the combination of MDM2 plus MEK inhibition elicited 93% decreases in tumor volume. This trial is to conduct a single-center, Phase 1

serum bilirubin
serum bilirubin level
metastatic colorectal cancer
renal function test
cancer
  • 19 views
  • 04 Oct, 2022
  • 1 location
Personalized Peptide Vaccine in Treating Patients With Advanced Pancreatic Cancer or Colorectal Cancer

This phase I trial studies the side effects and best way to give personalized peptide vaccine in patients with pancreatic or colorectal cancer that has spread to other places in the body and usually cannot be cured or controlled with treatment (advanced). Personalized peptide vaccine is a vaccine developed from …

pembrolizumab
cancer
tubal ligation
gilbert's syndrome
vasectomy
  • 11 views
  • 07 Oct, 2022
  • 1 location
Panitumumab With or Without Trametinib in Treating Patients With Stage IV Colorectal Cancer

This phase II clinical trial studies how well panitumumab with or without trametinib works in treating patients with stage IV colorectal cancer. Immunotherapy with monoclonal antibodies, such as panitumumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and …

  • 20 views
  • 04 Oct, 2022
  • 1 location
A Phase 1/2, First-in-Human, Open Label, Dose Escalation Study of MVC-101, An EGFR x CD3 COnditional Bispecific Redirected Activation (COBRA) Protein in Patients With Unresectable Locally Advanced or Metastatic Cancer

The main aim of this study is to check for side effects and tolerability of MVC-101 (also known as TAK-186) in adults with unremovable advanced or metastatic cancer. Another aim is to characterize and evaluate the activity of MVC-101 (TAK-186). Participants may receive treatment throughout the study for a maximum …

cetuximab
EGFR
epidermal growth factor
cancer chemotherapy
measurable disease
  • 5 views
  • 14 Oct, 2022
  • 2 locations
A Single-Arm Phase-II Study of Niraparib in Locally Advanced or Metastatic Solid Tumor Patients With PALB2 Mutations

The purpose of this study is to further evaluate the efficacy and safety of niraparib in patients with locally advanced or metastatic solid tumors and a pathogenic or likely pathogenic tumor PALB2 (tPALB2) mutation.

palb2
corticosteroid
formalin-fixed paraffin-embedded
solid tumor
  • 1 views
  • 11 Oct, 2022
  • 68 locations
A Multi-Center, Open-Label Study of Fruquintinib in Solid Tumors, Colorectal, and Breast Cancer

An open-label, dose escalation and expansion clinical trial to evaluate the safety, tolerability, and PK of fruquintinib in patients with advanced solid tumors, metastatic colorectal cancer and metastatic breast cancer.

triple negative breast cancer
tas-102
regorafenib
immunological adjuvant
cancer
  • 12 views
  • 07 Oct, 2022
  • 9 locations
18F-FMAU PET/CT and MRI for the Detection of Brain Tumors in Patients With Brain Cancer or Brain Metastases

This early phase I trial tests the use of a radioactive tracer (a drug that is visible during an imaging test) known as 18F-FMAU, for imaging with positron emission tomography/computed tomography (PET/CT) in patients with brain cancer or cancer that has spread to the brain (brain metastases). A PET/CT scan …

primary brain tumors
brain tumor
MRI
cancer
  • 0 views
  • 04 Oct, 2022
  • 1 location
A Phase II Study of High Dose Vitamin C Intravenous Infusion in Patients With Resectable or Metastatic Solid Tumor Malignancies

This is a multicenter, single arm, 3-cohort, open-label trial of high dose Vitamin C intravenous infusion in subjects with solid tumor malignancies who are eligible for resection (cohort A) or with extended RAS (e.g.KRAS or NRAS) or BRAF mutation metastatic cancer who have received prior systemic treatment (cohort B). Cohort …

potassium
cancer
KRAS
total bilirubin
NRAS
  • 18 views
  • 25 Oct, 2022
  • 2 locations
A Safety and Preliminary Efficacy Trial of Pembrolizumab (MK-3475) in Children With Recurrent, Progressive or Refractory Diffuse Intrinsic Pontine Glioma (DIPG), Non-Brainstem High-Grade Gliomas (NB-HGG), Ependymoma, Medulloblastoma or Hypermutated Brain Tumors

This phase I trial studies the side effects and best dose of pembrolizumab and to see how well it works in treating younger patients with high-grade gliomas (brain tumors that are generally expected to be fast growing and aggressive), diffuse intrinsic pontine gliomas (brain stem tumors), brain tumors with a …

monoclonal antibodies
biologics
cancer
mk-3475
cancer treatment
  • 111 views
  • 11 Oct, 2022
  • 3 locations