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Abdominal Cancer Clinical Trials

A listing of Abdominal Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (14) clinical trials

Intraperitoneal and Intravenous Paclitaxel Chemotherapy With Oral Capecitabine for Gastric Adenocarcinoma With Peritoneal Carcinomatosis

Background An estimated 28,000 cases of gastric adenocarcinoma are diagnosed annually in the U.S. Peritoneal metastasis is a common finding at diagnosis, making curative surgical resection possible in an estimated 25% of patients. Systemic chemotherapy is the recommended treatment for patients with metastatic gastric cancer to the peritoneal cavity, however …

Phase

Study of Chemotherapy With Pembrolizumab (MK-3475) Followed by Maintenance With Olaparib (MK-7339) for the First-Line Treatment of Women With BRCA Non-mutated Advanced Epithelial Ovarian Cancer (EOC) (MK-7339-001/KEYLYNK-001/ENGOT-ov43)

Following a lead-in period during which all participants receive a single 3-week cycle of carboplatin/paclitaxel, participants will be randomly assigned in to one of three treatment arms Pembrolizumab+Olaparib, Pembrolizumab+Placebo for Olaparib, or Placebo for Pembrolizumab+Placebo for Olaparib. At Investigator's discretion and prior to participant randomization, one of the following carboplatin/paclitaxel …

Phase

Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) With Oxaliplatin In Patients With Peritoneal Carcinomatosis

Gastric cancer is the 5th most common cancer (1 million incidences per year) and the third leading cause of cancer-related mortality worldwide (740,000 deaths per year). Unresectable gastric cancer is associated with a poor 5-year survival rate (< 30%) because of its late presentation with approximately 50% of the patients …

Phase

Comparison of "Roll-over' Technique With Standard Abdominal Paracentesis in Suspected Peritoneal Carcinomatosis

Trial Design The study will be a randomized comparison between two methods of abdominal paracentesis with a cross-over design and each participant will also serve as a control (standard paracentesis). Participants The study will be done on the patients who will visit Outpatient departments or admitted as an inpatient in …

Phase N/A

Nivolumab With or Without Ipilimumab in Treating Patients With Recurrent or High Grade Gynecologic Cancer With Metastatic Peritoneal Carcinomatosis

PRIMARY OBJECTIVES: I. To determine the recommended phase II dose (RP2D) of intraperitoneal (i.p.) nivolumab in combination with ipilimumab. SECONDARY OBJECTIVES: I. To describe the pharmacokinetics (PK), toxicities, and immune-related adverse events associated with i.p. checkpoint inhibitor therapy. II. To estimate the clinical benefit rate (rate of partial response [PR], …

Phase

Paclitaxel for the Treatment of Gastric or Gastroesophageal Cancer

PRIMARY OBJECTIVE: I. To assess the maximum tolerated dose (MTD) of paclitaxel via intraperitoneal route in subjects with gastric or gastroesophageal cancer and positive cytology or carcinomatosis. SECONDARY OBJECTIVES: I. Safety and tolerability of escalating doses of intraperitoneal paclitaxel in subjects with gastric or gastroesophageal cancer and positive cytology or …

Phase

Dosage of Epidural Morphine in Elderly Patients

Acute postoperative pain is a common complaint for several days after surgery. However, acute postoperative pain remains even more under controlled in elderly patients, especially those with cognitive impairment and malignancy. Geriatric population is reported to be at higher risk for unwanted side effects from analgesic treatments compared to younger …

Phase

Eribulin and Radiation in Treating Patients With Retroperitoneal Liposarcoma That Can Be Removed by Surgery

PRIMARY OBJECTIVE: I. To determine the recommended phase 2 dose (RP2D) of radiation and eribulin mesylate (eribulin) when used in combination for the preoperative treatment of retroperitoneal liposarcoma. SECONDARY OBJECTIVES: I. To assess the feasibility of a preoperative chemoradiation protocol for retroperitoneal liposarcoma. II. To assess the surgical outcomes of …

Phase

Dedicated MR Imaging vs Surgical Staging of Peritoneal Carcinomatosis in Colorectal Cancer

HYPOTHESIS Staging with dedicated MRI will lead to a reduction of staging laparoscopies and explorative laparotomies in colorectal patients with PM to evaluate whether they may benefit from CRS-HIPEC OBJECTIVES The goal is to perform a multicenter randomized study to compare a less invasive diagnostic workup ARM A (with MRI …

Phase N/A

IV Contrast-Enhanced Cone Beam Computed Tomography (CBCT) in Radiotherapy

The goal of this pilot study is to determine the feasibility and utility of administering IV contrast during a Cone Beam Computed Tomography (CBCT) in subjects who have image guided radiation therapy (IGRT) for the treatment of abdominal and pelvic tumors. Participant duration is one visit. Subjects will be required …

Phase N/A