Lung Disease Clinical Trials

A listing of Lung Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 437 clinical trials
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Efficacy and Safety of Pembrolizumab Plus Investigational Agents in Combination With Chemotherapy as First-Line Treatment in Extensive-Stage Small Cell Lung Cancer (ES-SCLC) (MK-3475-B99/ KEYNOTE-B99)

the first-line treatment of participants with extensive-stage small cell Lung Cancer (ES-SCLC). No formal hypothesis testing will be performed for this study.

pembrolizumab
measurable disease
cancer chemotherapy
carboplatin
etoposide
  • 0 views
  • 25 Nov, 2021
  • 27 locations
None
Safety and Efficacy Study of Pembrolizumab (MK-3475) in Combination With Investigational Agents for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)

This study is a rolling arm study of pembrolizumab in combination with investigational agents in participants with anti-programmed cell death 1 (PD-1)/ programmed cell death ligand 1 (PD-L1) refractory ES-SCLC in need of second-line treatment. This study will have 2 parts: an initial safety lead-in to determine safety and tolerability …

pembrolizumab
measurable disease
  • 0 views
  • 25 Nov, 2021
  • 27 locations
None
Platform Trial of Novel Regimens Versus Standard of Care (SoC) in Participants With Non-small Cell Lung Cancer (NSCLC)

This study will compare the clinical activity of novel regimens (in combination or as single agents) to SoC in participants with relapsed/refractory advanced NSCLC. The study will be conducted in two parts. Part 1 is an open-label, optional, non-randomized part based on safety and pharmacokinetics/pharmacodynamics (PK/PD) evaluation intended to generate …

docetaxel
metastasis
cancer chemotherapy
measurable disease
BRAF
  • 64 views
  • 18 Nov, 2021
  • 67 locations
None
HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer

This study is designed to evaluate the antitumor activity of patritumab deruxtecan in participants with metastatic or locally advanced NSCLC with an activating EGFR mutation (exon 19 deletion or L858R) who have received and progressed on or after at least 1 EGFR TKI and 1 platinum-based chemotherapy-containing regimen.

  • 3 views
  • 21 Nov, 2021
  • 108 locations
None
This Study Collects Information on the Safety of Inhaled Pegylated Adrenomedullin (PEG-ADM) How the Drug is Tolerated and How it Affects Patients Suffering From a Type of Lung Failure That Cause Fluid to Build up in the Lungs Making Breathing Difficult (ARDS)

placebo. ARDS is a type of lung failure that cause fluid to build up in the lungs making breathing difficult or impossible.

acute respiratory distress
sepsis
FIO2
effusions
ct scan
  • 2 views
  • 21 Nov, 2021
  • 60 locations
None
A Study to Test Whether Different Doses of Alteplase Help People With Severe Breathing Problems Because of COVID-19

This is a study in adults with severe breathing problems because of COVID-19. People who are in hospital on breathing support can participate in the study. The purpose of the study is to find out whether a medicine called alteplase helps people get better faster. The study has 2 parts. …

oximetry
assisted ventilation
intubation
ct scan
mechanical ventilation
  • 0 views
  • 25 Nov, 2021
  • 37 locations
None
Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

This ALCHEMIST trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. Studying the genes in a patient's

tumor cells
pemetrexed
metastasis
nivolumab
cancer
  • 1114 views
  • 28 Nov, 2021
  • 1140 locations
None
Study to Evaluate Adverse Events and Change in Disease Activity With Oral Capsules of Galicaftor/Navocaftor/ABBV-119 Combination Therapy in Adult Participants With Cystic Fibrosis

Cystic Fibrosis (CF) is a rare, life-threatening, genetic disease that affects the lungs and digestive system, significantly impairing the quality of life, with those affected having a median age of death at 40. The main objective of this study is to assess how safe and effective is the combination therapy …

ivacaftor
fibrosis
elexacaftor
forced expiratory volume
tezacaftor
  • 15 views
  • 21 Nov, 2021
  • 27 locations
None
Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II IIIA and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)

pembrolizumab alone after surgery [adjuvant phase] in participants with resectable stage II, IIIA, and resectable IIIB (T3-4N2) non-small cell lung cancer (NSCLC). The primary hypotheses of this study are that

platinum doublet
lung carcinoma
solid tumour
pemetrexed
pembrolizumab
  • 564 views
  • 27 Nov, 2021
  • 242 locations
None
A Global Study to Assess the Effects of Osimertinib Following Chemoradiation in Patients With Stage III Unresectable Non-small Cell Lung Cancer (LAURA)

lung cancer

epidermal growth factor
lung carcinoma
epidermal growth factor receptor
cancer chemotherapy
growth factor
  • 207 views
  • 27 Nov, 2021
  • 161 locations