Pediatric Health Clinical Trials

A listing of Pediatric Health medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 99 clinical trials
A Phase I Study of ASTX727 Plus Talazoparib in Patients With Triple Negative or Hormone Resistant/ Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Metastatic Breast Cancer

This is a Phase I study to test the safety of a combination of ASTX727 with talazoparib in patients with triple negative breast cancer or hormone resistant/HER2-negative metastatic breast cancer

stage iv breast cancer
erbb2
talazoparib
cancer
breast cancer
  • 1 views
  • 13 Oct, 2022
  • 2 locations
Neural and Psychological Mechanisms of Pain Perception

Background Painful stimuli cause changes in a network of brain regions called the "Pain Matrix." But most of these regions respond to many other stimuli, not just pain. Researchers want to understand how different factors influence pain. They want to test what happens when people expect different levels of pain …

heat
Accepts healthy volunteers
electrocardiogram
  • 240 views
  • 21 Oct, 2022
  • 1 location
TIL and Anti-PD1 in Metastatic Melanoma (ACTME)

The ACTME study is an investigator initiated, single center phase I/II clinical trial for patients with progressive unresectable stage III or stage IV melanoma. The trial consists of both a phase I part to determine safety and feasibility and a phase II part to evaluate first clinical activity of IFN-alpha, …

metastatic disease
brain metastases
hepatitis b
  • 31 views
  • 04 Oct, 2022
  • 1 location
Impact of Mesenchymal Stem Cells in Knee Osteoarthritis

Many patients with osteoarthritis of the knee fail non-operative measures and elect to have knee arthroplasty to improve their quality of life. If successful, intra-articular mesenchymal stem cell (MSC) injections into the knee may offer another viable non-operative treatment modality. Additionally, this modality may have reparative or regenerative potential, which …

Accepts healthy volunteers
chronic pain
total knee replacement
osteoarthritis
knee injury
  • 164 views
  • 07 Oct, 2022
  • 1 location
The Neurobiology of Suicide

Background There are no good treatments for people considering suicide. Researchers want to study suicide with questions, blood tests, brain imaging, and sleep studies. They hope to better understand suicide, so they can help suicidal people. Objective To understand what happens in the brain when someone has thought about or …

suicidal
Accepts healthy volunteers
suicide
depressed mood
ketamine
  • 611 views
  • 28 Oct, 2022
  • 1 location
Imaging Modalities for Melanoma Screening and Diagnosis

This trial studies how well MoleMapper, Visiomed, and confocal microscopy work in screening participants for melanoma. Analyzing images (photographs) made with three different portable imaging systems may be as good as a visit to a dermatologist's office for finding melanomas before they can spread.

Accepts healthy volunteers
nevus
cancer
skin cancer
shave biopsy
  • 43 views
  • 21 Oct, 2022
  • 1 location
Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated (TOMCATT)

Given the modest effectiveness of current treatments and the burden chronic neck pain places on Veterans, the investigators' research proposal is significant in several regards. First, Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated (TOMCATT) Study directly addresses a high priority area for the VA and is well aligned with the …

massage
sham treatment
cancer
pain relieving
analgesia
  • 168 views
  • 07 Oct, 2022
  • 1 location
Prevention of Chest Pain in Chemo-treated Cancer Patients (CATCH)

This is a prospective, exploratory, randomised clinical trial. Patients with diagnosed cancer that are to be treated with 5-fluorouracil (5-FU) will be randomised into standard oncological treatment or a cardiological assessment prior to the 5-FU treatment. The investigators hypothesize that aggressive management of ischemic risk factors in asymptomatic patients will …

fluorouracil
cancer
acute coronary syndrome
calcium
chest pain
  • 12 views
  • 04 Oct, 2022
  • 1 location
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder

Background Most medications that treat depression take weeks or months to work. Researchers want to develop fast-acting treatments. One dose of ketamine has a rapid antidepressant effect. For most people, this lasts a week or less. Repeated doses of ketamine may help maintain this effect. Objective Main Study: To study …

depression
polysomnography
Accepts healthy volunteers
transcranial magnetic stimulation
major depressive disorder
  • 2024 views
  • 27 Oct, 2022
  • 1 location
Screening Magnetic Resonance Imaging of the Brain in Patients With Breast Cancer

This research study is studying the usefulness of magnetic resonance imaging (MRI) to screen for brain metastases (spread of the breast cancer to the brain).

estrogen
MRI
cancer
estrogen receptor
her1
  • 2 views
  • 04 Oct, 2022
  • 1 location