Perimenopause Clinical Trials

A listing of Perimenopause medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 12 clinical trials
Cognitive Behavioural Therapy for Sexual Concerns During Perimenopause

Given the high rates and associated impairment of sexual concerns during the menopausal transition, and specifically during perimenopause, our team has developed a CBT protocol specifically

peri-menopausal
anxiety
hormone therapy
menstrual period
depression
  • 7 views
  • 04 Oct, 2022
  • 1 location
Impact of Estradiol on Endothelial Function in Peri-Menopausal Women

The purpose of this study is to identify the impact of estradiol (E2) on the mechanisms that regulate vascular endothelial function in peri-menopausal (PERI) women. This study is the first step in understanding factors contributing to endothelial dysfunction in women with advancing reproductive age and in response to E2 administration.

  • 18 views
  • 13 Feb, 2021
  • 1 location
A Neurosteroid Intervention for Menopausal and Perimenopausal Depression

HYPOTHESIS Pregnenolone administration will be associated with greater reduction in depressive symptom severity than placebo in women with current mMDD. STUDY AIMS: Primary Aim: Determine if pregnenolone is associated with greater reduction in depressive symptom severity than placebo in women with mMDD, as measured by MADRS. Secondary Aims: Determine if …

depressive symptoms
mirena
menstrual period
hot flashes
skyla
  • 486 views
  • 14 Jul, 2022
  • 1 location
Comparative Study to Evaluate the Efficacy and Safety of the Fixed-dose Combination of Estradiol / Dydrogesterone in Perimenopausal Women (Violet)

To obtain new data allowing personalizing continuous hormonal therapy in perimenopausal women in Russia, the following clinical study is going to be conducted in the Russian Federation:

  • 0 views
  • 23 Mar, 2022
  • 1 location
Effects of an ER Beta Agonist (Lilly Compound LY500307) on Estradiol-Withdrawal-Induced Mood Symptoms in Women With Past Perimenopausal Depression

Background Some women who had depression in the perimenopause may have mood symptoms again if they stop estrogen therapy. Estrogen acts in the brain and other

mood symptoms
estrogen
blood tests
probe
antidepressant
  • 232 views
  • 04 Oct, 2022
  • 1 location
Identifying Neurophysiological Mechanisms of Susceptibility to Estradiol Fluctuation and Irritability Symptoms in the Menopause Transition: An Experimental Approach

Women in the menopause transition (perimenopause) experience substantial day-to-day variability in estradiol and have a 2-4-fold increase in major depression risk. About 40% of perimenopausal

estrogen
mammogram
progesterone
Accepts healthy volunteers
estradiol
  • 2 views
  • 24 Oct, 2022
  • 1 location
Examining the Effects of Estradiol on Neural and Molecular Response to Reward (PEEPS)

This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function using simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR).

psychosis
anhedonia
anxiety
estradiol
  • 0 views
  • 29 Apr, 2022
  • 1 location
Autologous Platelet Rich Plasma (PRP) Intra Ovarian Infusion in Perimenopausal Women (PRP)

Autologous PRP intra ovarian infusion may improve ovarian response and women's hormonal profile and may promote folliculogenesis in perimenopausal women.

hormone replacement therapy
Accepts healthy volunteers
  • 111 views
  • 10 Feb, 2022
  • 1 location
Effectiveness of Electro-Press Needle for Menopause-associated Hot Flashes

The investigators plan to conduct the randomized controlled trial to evaluate the effectiveness of electro-press needle (EPN), a novel acupuncture needle combining shallow and gentle insertion with transdermal electrical stimulation, on menopause-associated hot flash in comparison with waiting-list group among women during menopausal transition and postmenopausal periods.

  • 3 views
  • 03 Jan, 2022
  • 1 location
The Evaluation of Women With Perimenopause-Related Mood and Behavioral Disorders

The purpose of this study is to investigate mood and behavior changes in the time period surrounding and including menopause. This is an observational study; volunteers who participate will not receive any new or experimental therapies. Controversy exists regarding the relationship between estrogen and progesterone (gonadal steroid) changes and midlife-onset …

estrogen
depressive symptoms
progesterone
antidepressants
Accepts healthy volunteers
  • 368 views
  • 21 Oct, 2022
  • 1 location