Aplastic Anemia Clinical Trials

A listing of Aplastic Anemia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 23 clinical trials
A Phase 1/2 Study of REGN7257 (Anti-Interleukin 2 Receptor Subunit Gamma [IL2RG] Monoclonal Antibody) in Patients With Severe Aplastic Anemia That Is Refractory to or Relapsed on Immunosuppressive Therapy

The primary objective of this study is to assess the safety and tolerability of REGN7257 in patients with immunosuppressive therapy (IST)-refractory or IST-relapsed severe aplastic anemia (SAA

  • 0 views
  • 16 Oct, 2022
  • 9 locations
A Randomized Trial of Sirolimus (Rapamune(R)) for Relapse Prevention in Patients With Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

Background People with severe aplastic anemia (SAA) do not make enough red and white blood cells, and/or platelets. Their body's immune system stops the bone

blood test
neutrophil count
immunosuppression
platelet count
cyclosporine
  • 14 views
  • 24 Oct, 2022
  • 1 location
Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

Background Severe aplastic anemia (SAA) is a rare and serious blood disorder. It causes the immune system to turn against bone marrow cells. Standard treatment for

blood disorder
blood test
neutrophil count
immunosuppression
eltrombopag
  • 12 views
  • 04 Oct, 2022
  • 1 location
A Randomized,Open-label Dose-discovery Study of PEG-rhG-CSF and rhG-CSF in the Adjuvant Therapy of Aplastic Anemia Granulocyte Deficiency

This study was a single-center,open-label,randomized,dose-exploring prospective study.Patients with granulocytotic aplastic anemia who received cytokine treatment with PEG-rhG-CSF or rhG-CSF

  • 0 views
  • 10 Oct, 2022
  • 1 location
The Safety and Efficacy Study of Avatrombopag Switch in TPO-RA Refractory AA

This study was a single-arm, multicenter, phase Π clinical study. Patients admitted to the enrollment unit center with a confirmed diagnosis of TDNSAA/VSAA/SAA, treated with IST (p/r-ATG+CSA) in combination with TPO-RA (including eltrombopta or hydtrombopta) for at least 3 months with no hematologic response at 6-month follow-up, and who were …

  • 0 views
  • 07 Oct, 2022
  • 1 location
Low Dose Danazol for the Treatment of Telomere Related Diseases

short telomeres and a specific gene change. They must also show signs of aplastic anemia, lung, or liver disease. Design Participants will be screened in another

  • 76 views
  • 19 Oct, 2022
  • 1 location
A Phase 4 Long-term Follow-up Study to Define the Safety Profile of Radium-223 Dichloride

Patients will be followed up in this study after prior treatment with BAY88-8223 / Radium-223 dichloride / Xofigo .

  • 0 views
  • 14 Oct, 2022
  • 78 locations
Collection of Granulocytes by Apheresis of Healthy Donors Stimulated With Filgrastim (G-CSF) and Dexamethasone

Background White blood cells called granulocytes help the body fight infection. People who have had chemotherapy or bone marrow transplants may have very low numbers of these cells. Transfusions of these cells can help improve the body's ability to fight infection. However, most of the cells are located in the …

Accepts healthy volunteers
  • 41 views
  • 28 Oct, 2022
  • 1 location
Haploidentical HCT for Severe Aplastic Anemia

This study is a prospective, single center phase II clinical trial in which patients with Severe Aplastic Anemia (SAA) ) will receive a haploidentical transplantation. The purpose of this study

fludarabine
glomerular filtration rate
red blood cell transfusion
ejection fraction
cyclophosphamide
  • 5 views
  • 07 Oct, 2022
  • 1 location
GVHD Prophylaxis by Addition of CD20 Monoclonal Antibody to the Conditioning Regimen in SAA With Treatment of Allo-HSCT

Objectives 2.1 Primary objectives To observe and compare incidence and severity of aGVHD and cGVHD between the two arms within 2 years after transplantation. To observe and compare the engraftment rate between the two arms. 3) To observe and compare the incidence of infections between the two arms. 2.2 Secondary …

fludarabine
cyclophosphamide
  • 0 views
  • 04 Oct, 2022
  • 1 location