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Brain Cancer Clinical Trials

A listing of Brain Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (95) clinical trials

People with recurrent or progressive brain metastases may be eligible for this trial.  All tumors will be submitted to the Alliance biorepository for tracking and processing.  Samples will undergo central biomarker testing.  Patient's tumor samples will be tested for the presence of mutations predicting sensitivity to each inhibitor.  Patients harboring …

Phase

People who are diagnosed with an oligodendroglioma and who haven't yet undergone treatment may be eligible.  This study is comparing two standard regimens, radiation followed by PCV (Procarbazine, CCNU, and Vincristine) or radiation with temozolomide during and after radiation, to see which is better.  

Phase

People who were previously diagnosed with an anaplastic astrocytoma (WHO grade III astrocytoma) and now have evidence that their tumor has returned or has tarted to grow again without concern that it has progressed to a glioblastoma (WHO grade IV astrocytoma) may be eligible to participate.  This study is comparing …

Phase

People who were previously diagnosed with glioblastoma (Grade IV) or Grade III glioma, and now have evidence that their tumor has come back or has started to grow again, and who would otherwise be getting surgery or a biopsy as part of their treatment may be eligible.  At the time …

Phase

People with either a new diagnosis of glioblastoma or with evidence that their tumor has returned or started to grow again may be eligible.  This trial is studying multiple treatment options, with the results of molecular testing on the tumor determining which arm(s) a person would qualify for.  This trial …

Phase

People who were just diagnosed with glioblastoma and have yet to get treatment may be eligible.  This trial is investigating whether a common blood pressure drug is helpful to prevent or diminish side effects of radiation when it is combined with the standard treatment for glioblastoma.  

Phase N/A

Pembrolizumab in Treating Younger Patients With Recurrent Progressive or Refractory High-Grade Gliomas Diffuse Intrinsic Pontine Gliomas Hypermutated Brain Tumors Ependymoma or Medulloblastoma

PRIMARY OBJECTIVES: I. To establish the safety and describe adverse effects associated with administration of the adult recommended dose of pembrolizumab (MK-3475) in each stratum separately. II. To estimate the sustained objective response rate, (complete response [CR] + partial response [PR], sustained for at least 9 weeks) associated with pembrolizumab …

Phase

Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children and Young Adults With High Grade or High-Risk Cancer and Their Caregivers

Background Children and young adults diagnosed with a high-grade or high-risk cancer (e.g., diffuse intrinsic pontine glioma, glioblastoma multiforme, relapsed-refractory leukemia, refractory metastatic sarcomas) face a poor prognosis given limited curative options. Recent research has indicated that this population of patients and their parents experience elevated stress and poorer health-related …

Phase N/A

Phase I-II Everolimus and Sorafenib in Recurrent High-Grade Gliomas

Background Although malignant gliomas display genetic heterogeneity, several key proliferation and survival signaling pathways have been identified. Recent work has focused on targeting these tumor specific pathways in hopes of improving treatment efficacy and minimizing treatment toxicity. Because molecularly targeted agents have been mostly ineffective when used alone, combination therapy …

Phase

Computer Training Program for Younger Patients With a Brain Tumor Who Underwent Radiation Therapy

PRIMARY OBJECTIVES: I. To assess the feasibility of a home-based, computerized, cognitive training program for patients with pediatric brain tumors who are undergoing cranial radiation therapy (CRT), treated in multiple Children Oncology Group (COG) institutions. EXPLORATORY OBJECTIVES: I. To estimate the effect size of this program on measures of attention …

Phase N/A