Neurologic Disorders Clinical Trials

The purpose of this study is to assess the effect of CK-2127107 versus placebo on respiratory function and other measures of skeletal muscle function in patients with ALS.

Systemic Sclerosis (SSc) is a devastating and often life threatening illness predominantly affecting women characterized by autoimmunity, widespread microvascular disease, and fibrosis, especially of the skin, gastrointestinal tract, and lung. Multiple studies have shown evidence of platelet activation in SSc. Chronic intermittent vasospasm in the microvasculature combined with platelet aggregation ...

We are studying patients with paraneoplastic neurologic disorders (The Hu syndrome, a.k.a. Paraneoplastic Subacute Sensory Neuropathy/Encephalomyelitis or Limbic Encephalopathy, and The Ri Syndrome, a.k.a. Paraneoplastic Opsoclonus-Myoclonus Ataxia) in two IRB-approved protocols at the Rockefeller University Clinical Research Center. One study is aimed at furthering our understanding of the cause of ...

This is an open-label trial. All NMO or NMO Spectrum Disorder (NMOSD) patients who have completed the double-blind, randomized, placebo-controlled ECU-NMO-301 (PREVENT) trial may be eligible to participate in this extension trial. Prior to initiating any extension trial procedures, an informed consent form must be signed and inclusion/exclusion criteria must ...

Neuromyelitis Optica (NMO) or NMO Spectrum Disorders (NMOSD), also known as Devic’s Disease, is a rare, severe disabling autoimmune inflammatory disorder of the central nervous system (CNS) that predominately affects the optic nerves and spinal cord, and is often characterized by a relapsing course. Throughout this protocol the term NMO ...

The Medtronic Sofamor Danek USA, Inc. CD HORIZON® LEGACY™ PEEK Rod Spinal System is currently marketed in both the US and EU and is designed to treat conditions of the lumbar spine as supplemental fixation for interbody fusion. The rods are made of polyetheretherketone (PEEK) with titanium tips or tantalum ...

The purpose of this study is to collect retrospective real-world clinical data to assess the performance including efficacy and safety of CD HORIZON® LEGACY™ PEEK Rod Spinal System used as supplemental fixation for a posterior interbody fusion cage in subjects who have undergone a posterior non-cervical spinal fusion procedure for ...

The PulseRider® Aneurysm Neck Reconstruction Device (ANRD) is a self-expanding nitinol implant designed to retain embolic coils at a vessel bifurcation. PulseRider® is comprised of the torque device, delivery wire, introducer, and implant. (Figure 1). The implant is provided attached to the delivery wire. The PulseRider system is intended to ...

The study is trying to understand what causes bipolar disorder and how medications treat bipolar depression. If you participate, you will have two different brain scans (an MRI and a PET scan) and antidepressant treatment for free. We will then be able to see whether information on the brain scans ...

Multicenter, randomized, double-blind, parallel-group, placebo-controlled, fixed-dosage, Phase 2a study comparing 3 dosages of LY3154207