Dermatomyositis (Connective Tissue Disease) Clinical Trials

A listing of Dermatomyositis (Connective Tissue Disease) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 180 clinical trials
Trial on Outpatients With Systemic Sclerosis Treated With Well-Being Therapy or With a Control Therapy

Systemic sclerosis (SSc) is a rare and potentially life-threatening autoimmune disorder with a significant impact on health and quality of life. The non-pharmacological interventions address to psychological sequalae currently available are limited and have poor efficacy. Well-Being Therapy (WBT) is a brief psychotherapy which has shown efficacy in decreasing the …

  • 0 views
  • 27 Jan, 2021
  • 2 locations
Neutrophil Extracellular Traps in Systemic Sclerosis

Systemic sclerosis (SSC) is a systemic disease characterized by limited or diffuse cutaneous sclerosis, microangiopathy, overproduction of autoantibodies and variable organ damage due to vasculopathy and/or fibrosis. The loss of self-tolerance is believed to be caused by the dysregulation of both innate and adaptive immune systems and may involve reactive …

vascular disease
lupus
fibrosis
progressive systemic sclerosis
immune tolerance
  • 79 views
  • 23 Jan, 2021
  • 1 location
Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis

Background Dermatomyositis (DM) and juvenile dermatomyositis (JDM) cause inflammation in the muscles. People with DM and JDM can develop calcium deposits in places they should not, known as calcinosis. Calcinosis can be painful and cause disabilities and other problems. Researchers want to learn more about calcinosis to find treatments for …

calcium
juvenile dermatomyositis
igiv
dermatomyositis
myositis
  • 76 views
  • 16 Sep, 2021
  • 1 location
Abatacept to Silence Anti-citrullinated Protein Antibody-expressing B Cells in Rheumatoid Arthritis (ASCARA)

To investigate the effect of CTLA4-Ig (abatacept) on phenotype, transcriptional profile, B cell receptor usage and functional parameters of circulating B cells expressing anticitrullinated protein antibodies (ACPA) in patients with early, methotrexate-nave, ACPA positive rheumatoid arthritis.

abatacept
absolute neutrophil count
arthritis
methotrexate
platelet count
  • 19 views
  • 24 Jan, 2021
  • 1 location
Effects of High-intensity Interval Training (HIIT) in Recent Onset Polymyositis and Dermatomyositis

Polymyositis and dermatomyositis are rare inflammatory systemic conditions. Reduced muscle function is a cardinal symptom and lung involvement is very common. Knowledge of heart involvement in these patients is very limited, as is knowledge of exercise effects in recent onset, active disease. The aim of this project is to investigate …

calcium
high-intensity interval training
dermatomyositis
gene expression
polymyositis
  • 18 views
  • 22 Jan, 2021
  • 1 location
A Study of FCX-013 Plus Veledimex for the Treatment of Moderate to Severe Localized Scleroderma (Morphea)

A two-component therapeutic consisting of FCX-013 and veledimex for the treatment of localized scleroderma (or morphea). The first component, FCX-013, is autologous human fibroblasts genetically-modified using lentivirus and encoded for matrix metalloproteinase 1 (MMP-1), a protein responsible for breaking down collagen. FCX-013 is designed to be injected under the skin …

immunosuppression
immunosuppressive agents
fibrosis
scleroderma
  • 27 views
  • 05 Feb, 2021
  • 2 locations
Allogeneic Bone Marrow Mesenchymal Stem Cells for Patients With Interstitial Lung Disease (ILD) & Connective Tissue Disorders (CTD)

Researchers are trying to find out more about the safety of a new treatment, Allogeneic (coming from a healthy donor) Bone Marrow Derived Mesenchymal Stem Cells (BMD-MSCs) which is still experimental, for Interstitial Lung Disease (ILD) associated with Connective Tissue Disorder (CTD).

pneumonia
pulmonary disease
interstitial lung disease
lung disease
connective tissue disorder
  • 273 views
  • 13 Jun, 2021
  • 1 location
Peer Approaches to Lupus Self-management

The Peer Approaches to Lupus Self-Management (PALS) study is a randomized, controlled in which 360 African American women with lupus will be recruited from the MUSC SLE database (60 mentors and 300 mentees). The peer mentoring intervention (patients will be matched with peer mentors who are considered competent in the …

lupus
  • 12 views
  • 03 Mar, 2021
  • 1 location
Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis

This is a 52 week, single center, randomized, double-blind, placebo-controlled study. After patients maintain a stable dose of Mycophenolate Mofetil (MMF) for at least 1 month, they will be randomized to treatment with either Belimumab & Rituximab or placebo.Patients in both groups will be on background MMF for the entirety …

MRSS
mycophenolate
lupus
fibrosis
progressive systemic sclerosis
  • 29 views
  • 26 Jan, 2021
  • 1 location
Evaluation of the Serum Soluble Fractalkine as a Biomarker of Pulmonary Fibrosis in Systemic Sclerosis

Systemic Scleroderma (SCS) is an autoimmune disease characterized by vascular involvement, a dysimmune condition, cutaneous and visceral fibrosis. Interstitial lung disease (ILD) affects 75% of SSc patients and is the leading cause of death in SSc. No diagnostic or prognostic biomarkers of SSc-associated ILD have been validated to date. The …

pulmonary disease
vascular disease
fibrosis
pulmonary fibrosis
pulmonary involvement
  • 0 views
  • 22 Jan, 2021
  • 1 location