Dermatomyositis (Connective Tissue Disease) Clinical Trials

A listing of Dermatomyositis (Connective Tissue Disease) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 183 clinical trials
Effect of Curcumin on Systemic Lupus Erythematosus

The purpose of this investigator initiated study is to determine the efficacy of curcumin on disease activity of subjects with systemic lupus erythematous. Curcumin has been found to have anti-inflammatory effects and has been found to improve disease activity in lupus patients. In addition, subjects with rheumatoid arthritis as well …

lupus
arthritis
treatment regimen
  • 3 views
  • 21 May, 2021
  • 1 location
A Study of ICP-022 in Patients With Systemic Lupus Erythematosus (SLE)

The purpose of the study is to assess the Safety, Tolerability, PK/PD and preliminary Efficacy of ICP-022 in Subjects with Systemic Lupus Erythematosus (SLE)

antinuclear antibody
lupus
  • 0 views
  • 31 May, 2021
  • 13 locations
Study of Anti-Malarials in Incomplete Lupus Erythematosus

This project is a multicenter, randomized, placebo-controlled, double-blind clinical trial that is designed to test whether treating patients who are at risk for development of lupus with hydroxychloroquine can slow accumulation of disease features. Effects on clinical progression of symptoms, patient-reported outcomes and changes in the immune markers of response …

lupus
antinuclear antibody
arthritis
antimalarials
hydroxychloroquine
  • 114 views
  • 26 Jan, 2021
  • 7 locations
Treatment of Dupuytren's Disease With Minimal Invasive Surgery and VIVOSORB Resorbable Implant Device

Dupuytren's disease is a progressive fibroproliferative condition of the hand which progresses in 20% of patients into a serious condition. In Flanders, Dupuytren's disease was found to be present in 32% of the population over 50 years. In severe flexion contracture finger deformity due to Dupuytren's disease, functional loss of …

  • 3 views
  • 26 Jan, 2021
  • 1 location
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome

This study evaluate the efficacy of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-COA) reductase inhibitors, also known as "statins" in the treatment of growth and skeletal abnormalities in children with Noonan syndrome. Half of patients will receive simvastatin while the other half will receive a placebo.

  • 24 views
  • 26 Jan, 2021
  • 20 locations
Relevance of Monitoring Blood and Salivar Levels of Drugs Used in Rheumatic Autoimmune Diseases

No drug treatment is completely free of risk and lack of response, adverse events and poor adherence may affect its effectiveness. Within this context, this project aims to evaluate the importance of monitoring blood levels and salivary drug used in rheumatic autoimmune diseases in the monitoring of adherence to therapy. …

biologics
elisa
tumor necrosis factor
glucocorticoids
hydroxychloroquine
  • 40 views
  • 26 Jan, 2021
  • 2 locations
Clinical Trial to Evaluate Efficacy and Safety of Dupilumab in Localized Scleroderma

The DupiMorph study evaluates the efficacy of Dupilumab in localized scleroderma patients. Dupilumab is approved in the US and EU for the treatment of moderate/severe atopic dermatitis and since 2018 in the US for severe asthma therapy.

  • 33 views
  • 24 Jan, 2021
  • 2 locations
Open-label Study of Tofacitinib for Moderate to Severe Skin Involvement in Young Adults With Lupus

This 76-week, 3-part Phase 1b/2 study is intended to evaluate the pharmacological properties (pharmacokinetics and pharmacodynamics), safety, tolerability and preliminary effectiveness of TOFA administrated to young adults (18-45 years) with moderately to severely active SLE-CL. Subjects will be studied at the Cincinnati Children's Hospital Medical Center (CCHMC) and in Cleveland …

lupus
leflunomide
tofacitinib
prednisone
  • 72 views
  • 09 Jul, 2021
  • 2 locations
Safety and Tolerability Study Of PF-06835375 In Subjects With Seropositive Systemic Lupus Erythematosus Or Rheumatoid Arthritis

This is a Phase 1 single and multiple dose escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06835375 in subjects with seropositive SLE or RA. The design is double-blind, sponsor open and placebo controlled. This study will include two parts: Part A and Part B. Part A …

antinuclear antibody
arthritis
lupus
rheumatoid factor
  • 1053 views
  • 09 Sep, 2021
  • 24 locations
Safety and Efficacy of Anaerobic Cultivated Human Intestinal Microbiome Transplantation in Systemic Sclerosis (ReSScue)

This study evaluates the effect of intestinal microbiota therapy on gastro-intestinal symptoms in patients with systemic sclerosis (SSc). This is a mulicenter randomized controlled trial conducted at university hospitals in Oslo, Troms, Bergen and Trondheim in Norway. In part A1, half of the patients will receive active substance (intestinal microbiota …

progressive systemic sclerosis
  • 20 views
  • 28 Apr, 2021
  • 4 locations