Dermatomyositis (Connective Tissue Disease) Clinical Trials

A listing of Dermatomyositis (Connective Tissue Disease) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 189 clinical trials
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Canadian Network for Autoimmune Liver Disease

CaNAL is a longitudinal observational cohort study of patients diagnosed with Primary Biliary Cholangitis (PBC), Autoimmune Hepatitis (AIH), or overlap syndrome. This study creates a nationwide registry and network focusing on high quality long-term follow-up of individual patient data from major Canadian centers. Primary Biliary Cholangitis (PBC) and Autoimmune Hepatitis …

recurrent disease
cirrhosis
liver transplant
overlap syndrome
cancer
  • 63 views
  • 14 Jun, 2021
  • 20 locations
None
Natural History of Rheumatic Diseases in Minority Communities

This study will explore the causes of rheumatic diseases and why many of them affect certain minority communities more severely. Rheumatic diseases may cause joint pain, stiffness or swelling. Some can involve bones, muscles, tendons or ligaments. Some cause abnormalities of the immune system the body s defense against disease. …

rheumatism
cell counts
swelling
arthralgia
stiffness
  • 40 views
  • 24 Oct, 2021
  • 1 location
None
Identification of New Biomarkers to Promote Personalized Treatment of Patients With Inflammatory Rheumatic Diseases

Introduction: The medical treatment of inflammatory rheumatic diseases has improved dramatically during the last decades primarily due to the introduction of biological disease modifying anti-rheumatic drugs (bDMARDs). However, bDMARD treatment failure occurs in 30-40% of patients due to lack of effectiveness or side effects. The tools to predict treatment outcomes …

connective tissue disorder
antirheumatics
psoriatic arthritis
connective tissue diseases
spondyloarthropathy
  • 286 views
  • 24 Jan, 2021
  • 12 locations
None
Glucocorticoid-induced Osteoporosis in Patients With Chronic Inflammatory Rheumatic Diseases or Psoriasis

Glucocorticoids remain to be among the most important and most frequently used anti-inflammatory and immunosuppressive or immune-modulatory acting drugs to treat rheumatic (and other) diseases. Unfortunately, glucocorticoids also exert undesired effects, especially if higher dosages have to be given over longer periods of time. The available data describing frequency and …

glucocorticoid therapy
immunosuppressive
glucocorticoids
rheumatic diseases
immunosuppressants
  • 17 views
  • 05 Feb, 2021
  • 2 locations
None
Pulmonary Hypertension Screening for Rheumatology Patients (SOPHIE)

Pulmonary arterial hypertension (PAH) is a serious and often fatal complication of connective tissue diseases including systemic sclerosis and systemic lupus erythematosus. It has been reported primarily from European series that the prevalence of PAH in patients with connective tissue diseases particularly systemic sclerosis is as high as 15-20%. However, …

rheumatism
pulmonary arterial hypertension
progressive systemic sclerosis
connective tissue disorder
systemic lupus erythematosus
  • 96 views
  • 10 Aug, 2021
  • 1 location
None
A Study of the Natural Progression of Interstitial Lung Disease (ILD)

We propose to acquire data and blood samples on all patients being cared for by the Interstitial Lung Disease (ILD) program. Additionally, we will collect data and blood samples from a control group for comparator purposes. In doing so, we will be able to describe the "phenotypic" expression of these …

interstitial lung disease
lung disease
pulmonary disease
  • 163 views
  • 23 Jan, 2021
  • 1 location
None
Study and Treatment of Inflammatory Muscle Diseases

This study of inflammatory muscle diseases-polymyositis and dermatomyositis and related disorders-will examine what causes these diseases and describe the clinical features (signs and symptoms) associated with them. Inflammation and degeneration of skeletal muscles in these disorders leads to weakness and muscle wasting. The skin, lungs and other organs may also …

polymyositis
MRI
urine tests
dermatomyositis
biopsy incision
  • 809 views
  • 25 Oct, 2021
  • 1 location
None
Adult and Juvenile Myositis

This study will evaluate subjects with adult- and childhood-onset myositis to learn more about their cause and the immune system changes and medical problems associated with them. Myositis is an inflammatory muscle disease that can damage muscles and other organs, resulting in significant disability. Children or adults with polymyositis or …

polymyositis
urine tests
MRI
damage muscles
dermatomyositis
  • 56 views
  • 24 Oct, 2021
  • 4 locations
None
Studies of the Natural History Pathogenesis and Outcome of Autoinflammatory Diseases Including Juvenile Dermatomyositis

Purpose The purpose of this protocol is 1. To comprehensively evaluate patients with autoinflammatory diseases clinically, genetically and immunologically at the autoinflammatory disease clinic at the NIH. 2. To follow patients with autoinflammatory Diseases that are genetically defined including Neonatal-Onset Multisystem Inflammatory Disease (NOMID), the most severe clinical phenotype of …

computerized tomography
deficiency
dermatomyositis
skin inflammation
x-rays
  • 497 views
  • 25 Oct, 2021
  • 1 location
None
Maternal Autoimmune Disease Research Alliance (MADRA) Registry

This multi-site registry, centered at Duke University, will enroll pregnant women with autoimmune and rheumatologic diseases. The main goal of MADRA is to identify ways to improve the health of women with rheumatic diseases and their babies during pregnancy. Prior studies demonstrate the importance of increase inflammation prior to and …

antiphospholipid antibodies
vasculitis
spondylitis
progressive systemic sclerosis
dermatomyositis
  • 239 views
  • 28 Jan, 2021
  • 1 location