Polymyositis (Inflammatory Muscle Disease) Clinical Trials

A listing of Polymyositis (Inflammatory Muscle Disease) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 19 clinical trials
A Study to Evaluate the Efficacy Safety and Pharmacokinetics of IgPro20 in Adults With Dermatomyositis (DM)

This is a phase 3, multicenter, randomized, placebo-controlled, double-blind study of IgPro20 (subcutaneous Ig) treatment in adult subjects with dermatomyositis (DM). The primary objective of this study is to assess the efficacy of IgPro20 subcutaneous (SC) doses in comparison to placebo in adult subjects with DM, as measured by responder …

rheumatism
corticosteroids
prednisolone
rash
myopathy
  • 13 views
  • 14 Jun, 2021
  • 103 locations
A Phase 2 Study of KZR-616 to Evaluate Safety and Efficacy in Patients With Active Polymyositis or Dermatomyositis

"This is a Phase 2 randomized, double-blind, placebo-controlled, crossover, multicenter study to evaluate the safety, tolerability, efficacy, Pharmacokinetics (PK) and Pharmacodynamics (PD) of treatment with KZR-616 in patients with active Polymyositis (PM) or Dermatomyositis (DM). Patients will be evaluated for eligibility during the Screening Period. Eligible patients will be randomized …

body mass index (bmi)
mdga
polymyositis
muscle enzyme
muscle biopsy
  • 85 views
  • 26 Jan, 2021
  • 29 locations
A Study In Adults With Moderate To Severe Dermatomyositis

A Study looking at Investigational drug and Placebo administered to adult Patients with moderate to severe Dermatomyositis

corticosteroids
experimental drug
dermatomyositis
rash
  • 122 views
  • 30 Jul, 2021
  • 32 locations
Effects of High-intensity Interval Training (HIIT) in Recent Onset Polymyositis and Dermatomyositis

Polymyositis and dermatomyositis are rare inflammatory systemic conditions. Reduced muscle function is a cardinal symptom and lung involvement is very common. Knowledge of heart involvement in these patients is very limited, as is knowledge of exercise effects in recent onset, active disease. The aim of this project is to investigate …

high-intensity interval training
polymyositis
dermatomyositis
cancer
calcium
  • 18 views
  • 22 Jan, 2021
  • 1 location
A Study of Ustekinumab in Participants With Active Polymyositis and Dermatomyositis Who Have Not Adequately Responded to One or More Standard-of-care Treatments

The purpose of this study is to evaluate the efficacy of ustekinumab in participants with active polymyositis (PM)/dermatomyositis (DM) despite receiving 1 or more standard-of-care treatments (for example, glucocorticoids and/or immunomodulators).

cyclosporine
polymyositis
tacrolimus
mycophenolate
aldolase
  • 8 views
  • 25 Mar, 2021
  • 38 locations
Exercise Capacity of Patients With Dermatomyosis

Dermatomyositis (DM) patients experience muscle weakness and low aerobic capacities, which are associated with poor health status and increased mortality. The origin of this muscle impairment remains unknown. The investigators hypothesize that mitochondria functioning is impaired in DM muscle and links with exercise capacities.

creatine kinase
myopathy
polymyositis
muscle biopsy
weakness
  • 0 views
  • 24 Jan, 2021
  • 1 location
Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis

Background Dermatomyositis (DM) and juvenile dermatomyositis (JDM) cause inflammation in the muscles. People with DM and JDM can develop calcium deposits in places they should not, known as calcinosis. Calcinosis can be painful and cause disabilities and other problems. Researchers want to learn more about calcinosis to find treatments for …

diabetes
juvenile dermatomyositis
igiv
urine tests
aldolase
  • 76 views
  • 01 Aug, 2021
  • 1 location
Phase 1 Study of ULSC in Patients With Polymyositis (PM) and Dermatomyositis (DM)

This study will investigate Umbilical Cord Lining Stem Cells (ULSC) as an investigational medicinal product and its use in patients with polymyositis (PM) or dermatomyositis (DM) to see if a single intravenous (IV) infusion of allogeneic umbilical cord lining stem cells (ULSC) safe, tolerable, and feasible to administer.

  • 0 views
  • 01 Aug, 2021
  • 1 location
Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study

Ectopic soft tissue calcifications or ossifications can complicate the course of numerous diseases; most of them are rare or very rare. Even if the clinical, radiological and pathological presentation of ectopic calcifications and ossifications are different, the same hypotheses are discussed considering their hypothetical pathophysiology. Indeed, high calcium phosphate product, …

progressive systemic sclerosis
calcium
computerized tomography
parathyroid hormone
dermatomyositis
  • 12 views
  • 25 Jan, 2021
  • 5 locations
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced Metastatic or Unresectable Cancer

This phase Ib trial studies the side effects of nivolumab and to see how well it works in treating patients with autoimmune disorders and cancer that has spread to other places in the body or cannot removed by surgery. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's …

carcinoma
computed tomography
neutrophil count
human chorionic gonadotropin
cytokines
  • 609 views
  • 01 Aug, 2021
  • 28 locations