Alpha 1 Antitrypsin Deficiency Clinical Trials

A listing of Alpha 1 Antitrypsin Deficiency medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 27 clinical trials
Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs

The purpose of this study is to look at how Alpha-1-antitrypsin (AAT) deficiency and Cystic Fibrosis (CF) affect white blood cells in the lungs, called macrophages, and their ability to work.

pulmonary disease
albuterol
pulmonary function test
deficiency
fibrosis
  • 138 views
  • 12 Sep, 2021
  • 1 location
Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease (A1BC)

Alpha-1 Anti-trypsin Deficiency (AATD) is a genetic disease with lung and liver disease presentations. The purpose of this study is to examine the density of the lung as measured by chest

emphysema
collection of sputum
deficiency
alpha1-proteinase inhibitor (human)
lung disease
  • 3 views
  • 28 Jul, 2022
  • 5 locations
Functional and Structural Lung Imaging in Chronic Obstructive Pulmonary Disease (FASTCOPD)

-anti-trypsin deficiency (A1ATD). These novel MRI measures will be compared to matched contemporary clinical diagnostic tools, namely pulmonary function tests (PFTs) and computed tomography (CT) scans

Accepts healthy volunteers
  • 0 views
  • 05 Jun, 2022
COPD Exacerbation Blood and Urine Biomarkers Study

This will be a prospective study examining serum levels of MMP-13 and alpha-1 antitrypsin as well as other biomarkers as well as urine biomarkers of smoking status and collagen degradation in the COPD patient population. Serum and urine biomarkers at baseline and after COPD exacerbations will be assessed against change …

alpha 1-antitrypsin
pulmonary function test
copd exacerbation
alpha1-proteinase inhibitor (human)
COPD
  • 25 views
  • 05 Aug, 2021
Optimization of Donor-Recipient Matching in Lung Transplantation (ADRTP)

-transplant prognosis, in front of a significant decrease in survival for patients with emphysema, chronic obstructive pulmonary disease, alpha-1 antitrypsin deficiency, transplanted with a smaller graft

  • 0 views
  • 15 Jul, 2022
  • 1 location
Longitudinal Study of Mitochondrial Hepatopathies (MITOHEP)

The specific aims of this study are (1) to determine the clinical phenotypes and natural history of hepatic RC and FAO disorders, (2) to determine the correlation between genotype and phenotype, (3) to determine if circulating biomarkers reflect diagnosis and predict liver disease progression and survival with the native liver, …

acyl carnitine
encephalopathy
mitochondrial disorder
mitochondrial hepatopathy
liver disease
  • 34 views
  • 28 Apr, 2022
  • 12 locations
An Integrative Genomic Approach to Solve tHe Puzzle of sevERe earLy-Onset COPD (SHERLOCk)

Chronic Obstructive Pulmonary Disease (COPD) is characterized by a chronic airflow limitation associated with an abnormal inflammatory response of the airways to inhaled noxious particles or gases. It is the third leading cause of death worldwide, accounting for approximately 3 million deaths each year and the prevalence is predicted to …

Accepts healthy volunteers
obstruction
plethysmography
spirometry
pulmonary function test
  • 1 views
  • 26 Feb, 2022
  • 2 locations