Alpha 1 Antitrypsin Deficiency Clinical Trials

A listing of Alpha 1 Antitrypsin Deficiency medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 24 clinical trials
Featured trial
Alpha-1 Study: A research study for individuals with Alpha-1 Antitrypsin Deficiency

The Alpha-1 Study is a clinical research study currently enrolling individuals 18 to 78 (inclusive) with Alpha-1 Antitrypsin Deficiency.   The purpose of this study is to evaluate

deficiency
alpha 1-antitrypsin
alpha1-proteinase inhibitor (human)
  • 240 views
  • 23 Nov, 2020
  • 7 locations
Featured trial
Role of Genetic Factors in the Pathogenesis of Lung Disease

This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. The study will focus on defining the distribution of abnormal genes responsible for processes …

diabetes
pulmonary disease
bronchoscopy
pulmonary fibrosis
  • 358 views
  • 23 Nov, 2020
  • 1 location
Study of OsrhAAT or Placebo in Healthy Volunteers

A Phase 1, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of Single Ascending Doses of OsrhAAT in Healthy Volunteers

Accepts healthy volunteers
absolute neutrophil count
body mass index
platelet count
  • 0 views
  • 06 May, 2022
  • 1 location
A Study of Belcesiran in Patients With A1ATD-Associated Liver Disease (ESTRELLA)

This is a multiple dose, randomized, placebo-controlled, double-blind study of belcesiran to evaluate the safety, tolerability, PK, and PD in adult patients with PiZZ A1ATD-associated liver

alpha1-proteinase inhibitor (human)
  • 2 views
  • 12 Jul, 2022
  • 14 locations
Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD) (SPARTA)

This is a multi-center, randomized, placebo-controlled, double blind clinical study to assess the efficacy and safety of two separate dose regimens of Alpha-1 MP versus placebo for 156 weeks (i.e., 3 years) using computed tomography (CT) of the lungs as the main measure of efficacy. The two Alpha-1 MP doses …

  • 761 views
  • 13 Mar, 2022
  • 44 locations
Evaluate Efficacy and Safety of "Kamada-AAT for Inhalation" in Patients With AATD (InnovAATe)

of adult patients with congenital alpha-1 antitrypsin (AAT) deficiency who have moderate airflow limitation (forced expiratory volume in 1 second 50% [FEV1] 80% of predicted) and FEV1/slow vital

forced expiratory volume
COPD
lung disease
inhalations
bronchodilator
  • 32 views
  • 21 Feb, 2022
  • 1 location
A First in Class Disease Modifying Therapy to Treat Alpha-1 Antitrypsin Deficiency a Genetically Linked Orphan Disease (ATALANTa)

oral administration of alvelestat (MPH966) in subjects with confirmed AATD defined as PiZZ, PiSZ, Pi*null, or another rare phenotype/genotype known to be associated with either low (serum AAT

COPD
deficiency
alpha1-proteinase inhibitor (human)
chronic obstructive pulmonary disease
emphysema
  • 498 views
  • 22 Sep, 2022
  • 10 locations
Single-centre Study Exploring the Utility of Hyperpolarized 129Xe Magnetic Resonance Imaging in Healthy Volunteers and Patients With Lung Disease

This is a single centre exploratory study that aims to apply hyperpolarized xenon-129 (129Xe) magnetic resonance imaging (MRI) methods and measurements in individual patients with and without lung disease to better understand lung structure and function and evaluate response to therapy delivered as a part of clinical care.

lung disease
bronchopulmonary dysplasia
malnourished
emphysema
trypsin
  • 551 views
  • 14 Sep, 2022
  • 1 location
Hyperpolarized 129Xe MRI for Imaging Pulmonary Function

The purpose of this study is to develop and evaluate the usefulness of MRI using 129Xe gas for regional assessment of pulmonary function. Specifically, three forms of 129Xe MRI contrast will be the investigators focus - 1) imaging of the 129Xe ventilation distribution, 2) imaging the alveolar microstructure via the …

lung disease
Accepts healthy volunteers
fibrosis
hypertension
assisted ventilation
  • 288 views
  • 21 Oct, 2021
  • 1 location
  • 0 views
  • 19 Aug, 2022
  • 5 locations