Alpha 1 Antitrypsin Deficiency Clinical Trials

A listing of Alpha 1 Antitrypsin Deficiency medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 12 clinical trials
A Study of Belcesiran in Patients With A1ATD-Associated Liver Disease (ESTRELLA)

This is a multiple dose, randomized, placebo-controlled, double-blind study of belcesiran to evaluate the safety, tolerability, PK, and PD in adult patients with PiZZ A1ATD-associated liver

alpha1-proteinase inhibitor (human)
  • 2 views
  • 04 Oct, 2022
  • 14 locations
Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency (ATALANTa)

oral administration of alvelestat (MPH966) in subjects with confirmed AATD defined as PiZZ, PiSZ, Pi*null, or another rare phenotype/genotype known to be associated with either low (serum AAT

deficiency
emphysema
COPD
chronic obstructive pulmonary disease
alpha1-proteinase inhibitor (human)
  • 498 views
  • 07 Oct, 2022
  • 10 locations
Evaluate Efficacy and Safety of "Kamada-AAT for Inhalation" in Patients With AATD (InnovAATe)

of adult patients with congenital alpha-1 antitrypsin (AAT) deficiency who have moderate airflow limitation (forced expiratory volume in 1 second 50% [FEV1] 80% of predicted) and FEV1/slow vital

pulmonary function test
blood test
chronic obstructive pulmonary disease
alpha1-proteinase inhibitor (human)
lung disease
  • 32 views
  • 04 Oct, 2022
  • 1 location
  • 0 views
  • 18 Oct, 2022
  • 3 locations
  • 0 views
  • 04 Oct, 2022
  • 6 locations
Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease

This is a single centre exploratory study that aims to apply hyperpolarized xenon-129 (129Xe) magnetic resonance imaging (MRI) methods and measurements in individual patients with and without lung disease to better understand lung structure and function and evaluate response to therapy delivered as a part of clinical care.

bronchopulmonary dysplasia
Accepts healthy volunteers
chronic obstructive pulmonary disease
sarcoidosis
sarcoidosis, pulmonary
  • 551 views
  • 07 Oct, 2022
  • 1 location
Hyperpolarized 129Xe MR Imaging of the Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

The purpose of this study is to develop and evaluate the usefulness of MRI using 129Xe gas for regional assessment of pulmonary function. Specifically, three forms of 129Xe MRI contrast will be the investigators focus - 1) imaging of the 129Xe ventilation distribution, 2) imaging the alveolar microstructure via the …

assisted ventilation
emphysema
hypertension
pulmonary disease
Accepts healthy volunteers
  • 288 views
  • 24 Oct, 2022
  • 1 location
Role of Genetic Factors in the Pathogenesis of Lung Disease

This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. The study will focus on defining the distribution of abnormal genes responsible for processes …

histiocytosis x
genetic disorder
diabetes
Accepts healthy volunteers
lymphatic disorders
  • 301 views
  • 28 Oct, 2022
  • 1 location
Respreeza® Self-administration and Learning Program (AmAREtTI Study) (AmAREtTI)

According to the Respreeza® Summary of Product Characteristics, the initial infusions must be administered under the supervision of a health professional experienced in the treatment of alpha-1

deficiency
alpha1-proteinase inhibitor (human)
self-administration
  • 49 views
  • 04 Oct, 2022
  • 10 locations
Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease (A1BC)

Alpha-1 Anti-trypsin Deficiency (AATD) is a genetic disease with lung and liver disease presentations. The purpose of this study is to examine the density of the lung as measured by chest

deficiency
collection of sputum
emphysema
lung disease
alpha1-proteinase inhibitor (human)
  • 3 views
  • 04 Oct, 2022
  • 5 locations