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Fever Clinical Trials

A listing of Fever medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (318) clinical trials

For the past 30 years, the laboratory of Clinical Microbiology/Immunology at The Rockefeller University has been studying Rheumatic Fever. For over one hundred years, the question of whether this disease has a genetic basis remains unresolved. In order to examine this question, we would like to contact the following: Families ...

Phase N/A

Phase III Trial to Evaluate Efficacy and Safety of a Tetravalent Dengue Vaccine

This is a randomized, multicenter, double-blind, placebo-controlled Phase III study that will evaluate efficacy and safety of a live attenuated, tetravalent, lyophilized dengue vaccine produced by Butantan Institute. The study will be carried out in multiple sites in Brazil. The study will be community-based in select urban areas where there's ...

Phase

Miltefosine/Paromomycin Phase III Trial for Treatment of Primary Visceral Leishmaniasis (VL) Patients in Eastern Africa

The 2 treatment regimens to be tested are: Arm 1: Paromomycin 20 mg/kg/d IM for 14 days combined with oral miltefosine allometric dosing for 14 days Arm 2: Paromomycin 20 mg/kg/d IM for 14 days combined with oral miltefosine allometric dosing for 28 days The reference arm is the current ...

Phase

Comparison of Arterolane-piperaquine Versus Arterolane-piperaquine+Mefloquine Versus Artemether-lumefantrine in Kenyan Children

This open-label randomised controlled clinical trial will compare the safety, tolerability, therapeutic efficacy and pharmacokinetics and pharmacodynamics of arterolane-piperaquine, arterolane-piperaquine plus mefloquine versus artemether-lumefantrine.in children with uncomplicated falciparum malaria in Kilifi, Kenya. This study will also provide an up to date insight on the current presence of antimalarial resistance in ...

Phase

Risk Factors & Outcomes for Clinically Documented Infections in Pediatric Cancer Patients With Fever & Neutropenia

Background It has long been recognized that not all neutropenic patients have the same risk of developing serious infections and/or complications. Fever and infection represent the most important complications of myeloablative cytotoxic therapy that results in severe mucositis and prolonged neutropenia . One of the most important concepts in the ...

Phase N/A

Scrub Typhus Antibiotic Resistance Trial

Study type: Randomized Control Treatment Trial Study population: Male and female patients with 15 years of age and acute scrub typhus Duration: 2 years Study Design: Prospective, open-label, randomized-controlled treatment trial in patients 15 years old admitted to hospital with acute scrub typhus. Randomization into 3 oral treatment arms (each ...

Phase

Malaria Genetic Surveillance

This is a prospective observational study of patients with clinical Plasmodium falciparum infection using parasite DNA from point-of-care fingerprick dried blood spot samples as well as a short survey on patient demographics, employment, travel, and mobile phone use to study P. falciparum parasite genotypes, population characteristics, and gene flow patterns. ...

Phase N/A

Balanced Salt Solutions vs. Normal Saline in Children With Septic Shock

Background Fluid resuscitation is the cornerstone of pediatric shock management; current practices of fluid resuscitation in children are not evidence based. Emerging data strongly indicate the increased incidence of hyperchloremic metabolic acidosis and consequently, acute kidney injury associated with infusion of large volumes of normal saline in critically ill adults ...

Phase N/A

A Challenge Study to Assess the Safety Immunogenicity and Efficacy of a Malaria Vaccine Candidate

This is a descriptive phase I trial to assess the safety and immunogenicity of the RH5.1/AS01 vaccine in healthy volunteers at different doses, and to establish whether the RH5.1/AS01 vaccine can demonstrate a reduced parasite multiplication rate in vaccinated subjects compared to infectivity controls in a blood-stage controlled human malaria ...

Phase

Mitochondrial DNA as a Biomarker of Sepsis Severity

Despite the advances of modern medicine, sepsis persists as one of the leading causes of death in the United States and poses a significant burden on U.S. health care, accounting for more than $24 billion of total hospital costs in 2013. The high mortality and cost of treating sepsis at ...

Phase N/A