Diabetic Kidney Disease Clinical Trials

A listing of Diabetic Kidney Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 58 clinical trials
Efficacy of a High-intensity Physical Activity Program on Renal Function in High Risk Patients With Type 2 Diabetes (ACTIDIANE)

Type 2 diabetes is a chronic condition whose prevalence is increasing globally. Kidney disease is a key complication of diabetes and is among the most common cause of end-stage renal disease, requiring renal replacement therapy. It has been shown that the trajectory of renal function (estimated glomerular filtration rate eGFR) …

kidney replacement
renal failure
type 2 diabetes mellitus
nephropathy
diabetes
  • 13 views
  • 03 Mar, 2022
  • 17 locations
Safety and Efficacy of Maximally Tolerated RAAS Blockade and Spironolactone Therapy on Urinary Proteinuria and Progression of Type II Diabetic Nephropathy in African Americans and Other Patient Cohorts. (MRA-ACE)

NephroNet proposes to examine whether combining Spironolactone with maximal RAAS blockade will further reduce urinary protein at one year and whether prolonged therapy (24 months) is able to slow the decline in GFR. Because of combination MRA and RAAS therapy significantly increases the risk for clinically significant hyperkalemia, we also …

renal function
diabetes
angiotensin
antihypertensive drugs
proteinuria
  • 34 views
  • 13 Oct, 2022
  • 2 locations
Effect of Heart-Protecting Musk Pill on Diabetic Microangiopaemia in Type 2 Diabetes Patients

The study mainly investigates the therapeutic effect of Heart-Protecting Musk Pill (HMP) on patients with diabetic microangiopathy. According to the indicators of diabetic nephropathy (DN

  • 0 views
  • 15 Oct, 2022
  • 1 location
Frailty, Inflammation, and Stem Cell Functionality in Chronic Kidney Disease

The proposed studies will examine the effect of fisetin on adipose tissue-derived mesenchymal stem/stromal cell function, kidney function, markers of inflammation, and physical function in individuals with advanced chronic kidney disease.

nephropathy
diabetes mellitus
diabetes
diabetic nephropathy
flavonoid
  • 66 views
  • 13 Oct, 2022
  • 1 location
Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy (RAISE-KT)

This randomized study evaluates the effect of subcutaneous semaglutide /in combination with lifestyle counseling in patients with type 2 diabetes mellitus (T2DM), overweight/obesity, and stage 4-5 chronic kidney disease (CKD) or dialysis-dependent end-stage kidney disease (ESKD) on patients' eligibility for kidney transplantation at the end of 9 months.

microalbumin/creatinine ratio
dialysis
diabetes
kidney transplant
heart failure
  • 0 views
  • 24 Mar, 2022
  • 1 location
Uric Acid Lowering Trial in Youth Onset T2D (ULTRA-T2D)

diabetic kidney disease (DKD) in youth with T2D over 7 years follow-up. Elevated SUA is thought to lead to cardiovascular disease (CVD) and DKD by inflammation, mitochondrial dysfunction and deleterious

cardiovascular disease
pegloticase
serum uric acid
type 2 diabetes mellitus
nephropathy
  • 1 views
  • 22 Mar, 2022
  • 1 location
The Fenofibrate And Microvascular Events in Type 1 Diabetes Eye.

The purpose of this study is to evaluate the potential benefits of 145 mg of daily fenofibrate in adults with type 1 diabetes mellitus and pre-existing non-proliferative diabetic retinopathy.

retinopathy
diabetic retinopathy
insulin
diabetes
type 1 diabetes mellitus
  • 22 views
  • 21 Jun, 2021
  • 21 locations
Effect of Taurine on Glycemic, Lipid and Inflammatory Profile in Individuals With Type 2 Diabetes (TAUGLIP-DM2)

, animal models showed that taurine had a protective effect from diabetic nephropathy. The hypothesize of this study is that taurine administration improves the glycemic, lipid, inflammatory, and

  • 0 views
  • 23 Mar, 2022
Impact of Metabolic Surgery on Pancreatic, Renal and Cardiovascular Health in Youth With Type 2 Diabetes (IMPROVE-T2D)

adult-onset T2D, youth with T2D have a more aggressive phenotype with greater insulin resistance (IR), more rapid β-cell decline and higher prevalence of diabetic kidney disease (DKD), arguing for

cardiovascular disease
insulin resistance
insulin sensitivity
pancreatic failure
gastrectomy
  • 97 views
  • 24 Mar, 2022
  • 1 location
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin (DEFINE)

occurred prior to diagnosis. Diabetes is associated with the development of microvascular complications (diabetic nephropathy, neuropathy, and retinopathy), and macrovascular complications (coronary artery

hyperglycemia
insulin resistance
hypoglycemic agents
stroke
Accepts healthy volunteers
  • 15 views
  • 14 Mar, 2022
  • 1 location