Sinusitis Clinical Trials

A listing of Sinusitis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 48 clinical trials
In-clinic Endoscopic Polypectomy for Chronic Sinusitis With Nasal Polyps

Chronic rhinosinusitis, also called chronic sinusitis, is a very common life-long disease affecting over 5% of the Canadian population. Its symptoms, including daily facial pain and headache, an

rhinosinusitis
rhinoscopy
headache
nasal endoscopy
medical therapy
  • 1280 views
  • 27 Jan, 2022
  • 4 locations
Endoscopic Sinus Surgery in Recurrent Acute Rhinosinusitis

The aim of this study is to find out if endoscopic sinus surgery improves the quality of life in patients suffering from recurrent acute rhinosinusitis. Our main outcome is the difference between the average change in disease-specific SNOT-22 quality of life questionnaire scores (from baseline to 5-6 months follow-up) between …

rhinosinusitis
antibiotics
antibiotic therapy
acute sinusitis
hyposmia
  • 81 views
  • 26 Jan, 2021
  • 1 location
Efficacy and Safety of Modified Release Cefpodoxime Formulation in the Treatment of Acute Sinusitis.

The aim of this study is to compare the efficacy and safety of cefpodoxime 200 mg immediate (b.i.d) and cefpodoxime 400 mg modified release (q.d) tablet formulations in the treatment of acute bacterial rhinosinusitis.

rhinosinusitis
headache
acute sinusitis
obstruction
facial pain
  • 15 views
  • 18 Dec, 2021
  • 2 locations
Pain Management Following Sinus Surgery

This Study evaluates the effect of adding Non-steroidal anti-inflammatories (NSAIDs) to the post-operative pain management of sinus surgery patients and wether or not this addition reduces or eliminates the need for narcotic pain medications. Patients will be instructed to take an NSAID regimen after surgery and will be instructed to …

postoperative pain
analgesia
narcotics
ibuprofen
anti-inflammatory agent
  • 6 views
  • 25 Jul, 2021
  • 2 locations
Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis

The purpose of this pilot study is to explore wither ivacaftor in refractory CRS patients will demonstrate safety and tolerability; restore CFTR-mediated Cl- secretions as measured by EDSPD testing; produce detectable improvements in validated measures of CRS including the SNOT-22 questionnaire, Lund-MacKay CT scan grading, and Lund-Kennedy endoscopic scores; and …

rhinosinusitis
ct scan
ivacaftor
cavities
  • 6 views
  • 28 Jun, 2021
  • 1 location
Topical Antibiotics in Chronic Rhinosinusitis

There is a certain group of patients that has chronic rhinosinusitis that has continued even with treatment including saline and steroid nasal irrigations as well as oral steroids and antibiotics and surgery. In these patients, the use of topical antibiotic nasal rinses may be of benefit to their disease. The …

rhinosinusitis
sinus surgery
antibiotics
endoscopy
ethmoidectomy
  • 28 views
  • 27 Jan, 2021
  • 1 location
Nitric Oxide Releasing Sinus Irrigation (NOSi) to Treat Recalcitrant Chronic Rhinosinusitis (RCRS)

This a single center, randomized controlled trial to evaluate safety & efficacy of topical nitric oxide releasing sinus irrigation (NOSi) as compared to budesonide-Saline (Control) in the management of biofilm-associated recalcitrant chronic rhinosinusitis (RCRS). It is hypothesized that a daily treatment of NOSi over a 6-week period will be safe …

budesonide
rhinosinusitis
antibiotics
sinus surgery
antibiotic therapy
  • 13 views
  • 19 Feb, 2021
  • 1 location
The Causal Relation of Nasal Nitric Oxide Levels to the Severity of Chronic Rhinosinusitis and Its Inflammatory Phenotype

the relation of chronic rhino sinusitis (CRS) severity and inflammatory status to nNO, maxillary sinus NO, nitrite, nitrate and cone beam computed tomography (CBCT). Three groups (22 patients

nitrite
asthma
rhinosinusitis
ct scan
  • 0 views
  • 24 Jan, 2021
  • 1 location
Functional Endoscopic Sinus Surgery Study

The aim of this study is to evaluate the effect of the addition of epinephrine to bilateral real time ultrasound guided pterygopalatine ganglion blocks on intra-operative bleeding and blood loss during functional endoscopic sinus surgery (FESS).

sinus surgery
  • 0 views
  • 20 Oct, 2021
  • 1 location
Efficacy of Dupilumab for Patients With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)

The overarching objective of this study is to determine the clinical effectiveness of dupilumab for the treatment of CRS that includes several potential disease endotypes with the exclusion of the nasal polyp cluster that has previously been determined. The additional information gained from secondary and exploratory outcomes will help provide …

rhinosinusitis
nasal polyp
antibiotics
endoscopy
eosinophil count
  • 165 views
  • 18 Oct, 2021
  • 1 location