Sickle Cell Disease Clinical Trials

A listing of Sickle Cell Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 226 clinical trials
Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMTCTN1507)

This is a Phase II, single arm, multi-center trial, designed to estimate the efficacy and toxicity of haploidentical bone marrow transplantation (BMT) in patients with sickle cell disease (SCD

bone marrow transplant
anti-thymocyte globulin
acute chest syndrome
carbon monoxide
asthma
  • 219 views
  • 22 Mar, 2022
  • 26 locations
Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell Disease

allogeneic hematopoietic stem cell transplantation from a haploidentical donor in patients with sickle cell disease. The overall goal of this study is to expand the donor pool for hematopoietic stem

acute chest syndrome
thalassemia
preparative regimen
anemia
asthma
  • 14 views
  • 02 Feb, 2022
  • 1 location
Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantation

This study aims to enroll 58 pre-adolescent (<13 years) pediatric participants with sickle cell disease (SCD) who have a pre-adolescent sibling bone marrow donor. All participants will go

bone marrow transplant
acute chest syndrome
transplant conditioning
transcranial doppler ultrasonography
chest syndrome
  • 23 views
  • 12 Feb, 2022
  • 10 locations
Peripheral Blood Stem Cell Collection From Patients With Sickle Cell Disease (SCD) Using Plerixafor

With recent advances in gene editing, gene therapy is becoming a viable curative treatment option for sickle cell disease. In order to do genetic manipulation, investigators need to collect

conjugated bilirubin
hydroxyurea
apheresis
gene therapy
plerixafor
  • 0 views
  • 13 Jun, 2022
  • 1 location
An Indian Multi-centric Phase IV Study to Assess the Safety of Crizanlizumab in Sickle Cell Disease Patients

Sickle cell disease (SCD) is a genetic blood disorder. Crizanlizumab has been approved in India and other countries to reduce the frequency of vaso-occlusive crises (VOCs) in patients with SCD

conjugated bilirubin
blood disorder
electrophoresis
absolute neutrophil count
  • 14 views
  • 27 Apr, 2022
  • 7 locations
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of FTX-6058

This is a study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of FTX-6058 in subjects with sickle cell disease.

opioid
vaso-occlusive crisis
hydroxyurea
body mass index
absolute neutrophil count
  • 0 views
  • 30 Jun, 2022
  • 5 locations
Glutamine Role in Preventing Vaso-occlusive Crisis Among SCD Patients (Glu_SCD_Egy)

Prospective phase IV interventional open label randomized controlled trial to assess safety and efficacy of glutamine in preventing vaso-occlusive crisis (VOC) episodes in sickle cell pediatrics and adolescents' patients

hydroxyurea
vaso-occlusive crisis
electrophoresis
glutamine
blood transfusion
  • 0 views
  • 27 Jun, 2022
  • 2 locations
Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease (NYMC-571)

This is a follow-up trial to NYMC 526 (NCT01461837) to assess the safety, efficacy and toxicity of administering Defibrotide prophylaxis for high-risk sickle cell or beta thalassemia patients undergoing a familial haploidentical allogeneic stem cell transplantation with CD34 enrichment and T-cell addback. This patient population historically has a risk of …

acute chest syndrome
thalassemia
tricuspid regurgitant jet velocity
hemoglobin s
cell transplantation
  • 18 views
  • 30 Jun, 2022
  • 3 locations
Age of Blood in Sickle Cell Transfusion

Transferrin Bound Iron(NTBI) that leads to increased rates of infection in adults with Sickle Cell Disease(SCD). To test this hypothesis, the study staff will perform a randomized prospective clinical

hemoglobin s
transferrin
sickle hemoglobin
thalassemia
iron
  • 16 views
  • 12 Mar, 2022
  • 2 locations
Pediatric -Adult Care Transition Program of Patients With Sickle Cell Disease (DREPADO)

upheavals and adaptations of family roles. During this period, medication adherence is non-optimal and absenteeism at medical appointments is high. Sickle cell disease (SCD) is the first genetic

acute chest syndrome
adult care
hemoglobinopathy
thalassemia
stroke
  • 1 views
  • 05 May, 2022
  • 1 location