Sickle Cell Disease Clinical Trials

A listing of Sickle Cell Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 228 clinical trials
Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia (MitoQ)

MitoQ is commercially available as a dietary supplement and it has been tested as a potential drug in other diseases, but it has never been tested in patients with sickle cell disease.

anemia
Accepts healthy volunteers
  • 0 views
  • 25 Mar, 2022
  • 5 locations
Safety and Efficacy of Gene Therapy of the Sickle Cell Disease by Transplantation of an Autologous CD34+ Enriched Cell Fraction That Contains CD34+ Cells Transduced ex Vivo With the GLOBE1 Lentiviral Vector Expressing the βAS3 Globin Gene in Patients With Sickle Cell Disease (DREPAGLOBE) (DREPAGLOBE)

The purpose of this study is to evaluate the Safety and Efficacy of Gene Therapy of the Sickle Cell disease by Transplantation of an Autologous CD34+ enriched cell fraction that contains CD34

electrophoresis
gene therapy
acute chest syndrome
hydroxyurea
priapism
  • 0 views
  • 26 Jan, 2022
  • 1 location
Safety of Single Doses of CSL889 in Adult Patients With Sickle Cell Disease

biomarkers of target engagement of CSL889 following single intravenous (IV) doses in subjects with sickle cell disease (SCD). The study involves sequential dose escalation of cohorts with between-group

glutamine
hydroxyurea
thalassemia
  • 0 views
  • 07 Apr, 2022
  • 9 locations
Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) for Patients With Severe Sickle Cell Disease

The purpose of this study is to develop a safe and curative stem cell transplant approach to treating sickle cell disease by assessing the safety of haploidentical hematopoietic stem cell

cell transplantation
narcotics
acute chest syndrome
hydroxyurea
chest syndrome
  • 0 views
  • 26 Jan, 2022
  • 1 location
Building Adaptive Coping and Knowledge to Improve Daily Life (Back2Life)

The purpose of this study is to find out how teenagers with chronic pain and sickle cell disease respond to a new training program called Back2Life and get their feedback about how to modify the

hydroxyurea
chronic pain
  • 0 views
  • 21 Apr, 2022
  • 3 locations
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of FTX-6058

This is a study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of FTX-6058 in subjects with sickle cell disease.

vaso-occlusive crisis
body mass index
opioid
hydroxyurea
absolute neutrophil count
  • 0 views
  • 22 Apr, 2022
  • 1 location
Pharmacokinetics and Pharmacodynamics of Rifaximin Novel Formulations in Patients With Sickle Cell Disease

This is a randomized, double-blind, placebo-controlled study in sickle cell disease participants with a history of Vaso-occlusive Crises (VOCs). Approximately 60 participants with sickle cell

absolute neutrophil count
electrophoresis
hydroxyurea
conjugated bilirubin
thalassemia
  • 0 views
  • 23 Apr, 2022
Myeloablative Conditioning, Prophylactic Defibrotide and Haplo AlloSCT for Patients With Sickle Cell Disease (NYMC-571)

This is a follow-up trial to NYMC 526 (NCT01461837) to assess the safety, efficacy and toxicity of administering Defibrotide prophylaxis for high-risk sickle cell or beta thalassemia patients undergoing a familial haploidentical allogeneic stem cell transplantation with CD34 enrichment and T-cell addback. This patient population historically has a risk of …

sickle hemoglobin
hemoglobin c disease
tricuspid regurgitant jet velocity
sickle cell trait
hemoglobin s
  • 18 views
  • 22 Apr, 2022
  • 3 locations
EXTEND EXpanding Treatment for Existing Neurological Disease

The primary goal of the Phase II EXTEND trial is to investigate the effects of open-label hydroxyurea treatment, escalated to maximum tolerated dose, for children with Sickle Cell Anemia and

transcranial doppler ultrasonography
hydroxyurea
anemia
stroke
thalassemia
  • 19 views
  • 24 Apr, 2022
  • 1 location
A Study to Assess the Safety, Tolerability, and Efficacy of BIVV003 for Autologous Hematopoietic Stem Cell Transplantation in Patients With Severe Sickle Cell Disease (PRECIZN-1)

This is an open label, multicenter, Phase 1/2 study in approximately eight adults with severe Sickle Cell Disease (SCD). The study will evaluate the safety, tolerability, and efficacy of

sickle hemoglobin
plerixafor
analgesia
cancer
cell transplantation
  • 15 views
  • 24 Apr, 2022
  • 6 locations