Sickle Cell Disease Clinical Trials

A listing of Sickle Cell Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 223 clinical trials
Hydroxyurea Optimization Through Precision Study (HOPS)

Hydroxyurea Optimization through Precision Study (HOPS) is a prospective, multi-center, randomized trial that will directly compare a novel, individualized dosing strategy of hydroxyurea to standard weight-based dosing for children with SCA. The primary objective of the study is to evaluate whether a pharmacokinetics-based starting hydroxyurea dose thieves superior fetal hemoglobin …

anemia
hydroxyurea
sickle hemoglobin
thalassemia
hemoglobin f
  • 82 views
  • 10 Feb, 2022
  • 12 locations
Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantation

This study aims to enroll 58 pre-adolescent (<13 years) pediatric participants with sickle cell disease (SCD) who have a pre-adolescent sibling bone marrow donor. All participants will go

fludarabine
stroke
melphalan
blood transfusion
opioid
  • 23 views
  • 12 Feb, 2022
  • 10 locations
Comparing Individualized vs. Weight Based Protocols to Treat VOE in SCD Occlusive Episodes in Sickle Cell Disease (COMPARE-VOE)

The purpose of this research study is to compare two different ways to give opioid pain medicine to treat sickle cell disease pain that is bad enough to go to the emergency department for

analgesics
morphine
thalassemia
opioid
hemoglobin s
  • 12 views
  • 16 Feb, 2022
  • 6 locations
Inhaled Mometasone to Promote Reduction in Vasoocclusive Events 2 (IMPROVE2)

Sickle Cell Disease (SCD) who report episodic cough or wheeze (ECW) but do not have asthma. Patients will be recruited from and followed in SCD clinics at participating sites. The primary endpoint will

asthma
hydroxyurea
cough
hemoglobin s
  • 9 views
  • 23 Feb, 2022
  • 2 locations
Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE) (SCD-CARRE)

The SCD-CARRE trial is a Phase 3, prospective, randomized, multicenter, controlled, parallel two-arm study aimed to determine if automated exchange blood transfusion and standard of care administered to high mortality risk adult SCD patients reduces the total number of episodes of clinical worsening of SCD requiring acute health care encounters …

hydroxyurea
anti-thymocyte globulin
sickle hemoglobin
thalassemia
blood transfusion
  • 24 views
  • 17 Mar, 2022
  • 16 locations
A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease

A randomized control trial in 20 subjects with sickle cell disease comparing oral THU-decitabine to nicotinamide and in combination (THU, decitabine and nicotinamide).

electrophoresis
hydroxyurea
chest syndrome
narcotics
acute chest syndrome
  • 0 views
  • 14 Apr, 2022
  • 1 location
A Study to Assess the Safety, Tolerability, and Efficacy of BIVV003 for Autologous Hematopoietic Stem Cell Transplantation in Patients With Severe Sickle Cell Disease (PRECIZN-1)

This is an open label, multicenter, Phase 1/2 study in approximately eight adults with severe Sickle Cell Disease (SCD). The study will evaluate the safety, tolerability, and efficacy of

stroke
asthma
chest syndrome
cancer
acute chest syndrome
  • 0 views
  • 08 Apr, 2022
  • 5 locations
Escalation of Plerixafor for Mobilization of CD34+ Hematopoietic Progenitor Cells and Evaluation of Globin Gene Transfer in Patients With Sickle Cell Disease

collection in cancer patients. It is not yet approved for patients with sickle cell disease. The investigators want to find out if Plerixafor can be used to increase cell counts in patients with sickle cell

plerixafor
absolute neutrophil count
cancer
gene therapy
thalassemia
  • 34 views
  • 18 Apr, 2022
  • 1 location
Study to Evaluate the Effect of GBT440 in Pediatrics With Sickle Cell Disease (HOPE Kids)

This study consists of four parts, Parts A, B, C, and D. Part A is a single dose pharmacokinetic (PK) study in pediatric participants with Sickle Cell Disease ages 6 to 17 years

sickle cell trait
voxelotor
hydroxyurea
sickle hemoglobin
thalassemia
  • 2 views
  • 25 Mar, 2022
  • 12 locations
Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia (MitoQ)

MitoQ is commercially available as a dietary supplement and it has been tested as a potential drug in other diseases, but it has never been tested in patients with sickle cell disease.

anemia
Accepts healthy volunteers
  • 0 views
  • 25 Mar, 2022
  • 5 locations