Sickle Cell Disease Clinical Trials

A listing of Sickle Cell Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 301 clinical trials
PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST) (PROTEST)

This is a pilot study, phase III, multi-centre, double blind, randomized controlled trial of patients with traumatic brain injury (TBI).

severe traumatic brain injury
subarachnoid hemorrhage
traumatic brain injury
  • 16 Feb, 2022
  • 10 locations
A Trial to Assess the Effect of Transfusion Strategies on Fatigability Levels After Hospital Discharge (EToF)

This study is a randomized controlled trial in which hospitalized patients with anemia are randomized to receive transfusion at: a) Hb<9g/dL (liberal transfusion strategy), or b) Hb<7g/dL (restrictive transfusion strategy). We are measuring self-reported fatigability, fatigue, and activity levels at randomization and 7 days post hospital discharge in both trial …

red blood cell transfusion
  • 05 Jun, 2022
  • 1 location
The Swedish BioFINDER 2 Study (BioFINDER2)

The Swedish BioFINDER 2 study is a new study that will launch in 2017 and extends the previous cohorts of BioFINDER 1 study ( BioFINDER 1 is used e.g. to characterize the role of beta-amyloid pathology in early diagnosis of Alzheimer's disease (AD) using amyloid-PET (18F-Flutemetamol) and A analysis in …

neurodegenerative disorder
parkinson's disease
psychiatric disorders
mini-mental state examination
cognitive impairment
  • 25 Feb, 2022
  • 1 location
Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE) (SCD-CARRE)

The SCD-CARRE trial is a Phase 3, prospective, randomized, multicenter, controlled, parallel two-arm study aimed to determine if automated exchange blood transfusion and standard of care

anti-thymocyte globulin
blood transfusion
exchange transfusion
sickle hemoglobin
  • 26 May, 2022
  • 17 locations
Fitness Trial in Adults With Sickle Cell Disease (SCD Fit): A Feasibility Study

The purpose of this project is to develop novel approaches to promote health and longevity while enhancing quality of life among persons with Sickle cell disease (SCD). Therefore, investigators

vaso-occlusive crisis
  • 26 Jan, 2022
  • 1 location
Peripheral Blood Stem Cell Collection From Patients With Sickle Cell Disease (SCD) Using Plerixafor

administration of plerixafor in pediatric and young adult patients with sickle cell disease (SCD). To estimate the number of CD34+ cells/kg of body weight that can be collected with peripheral

conjugated bilirubin
gene therapy
blood transfusion
  • 09 Aug, 2022
  • 1 location
Cutaneous Hydration Assessment in SCD

status and its potential to guide hydration therapy in patients with sickle cell disease (SCD).

  • 26 Apr, 2022
Sleep Apnea in Sickle Cell Disease (DREPAPNEE)

pathophysiological mechanisms are scarce. OSA is one of the most common conditions responsible for hemoglobin desaturation. The nocturnal hemoglobin desaturation occurring in some sickle cell disease (SCD) patients

sickle cell trait
vaso-occlusive crisis
sickle hemoglobin
blood transfusion
hemoglobin s
  • 01 Feb, 2022
  • 3 locations
Evaluation of Safety and Efficacy of CTX001 in Pediatric Participants With Severe Sickle Cell Disease (SCD)

This is a single-dose, open-label study in pediatric participants with severe SCD and hydroxyurea (HU) failure or intolerance. The study will evaluate the safety and efficacy of autologous

  • 13 Jun, 2022
  • 1 location
T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias

The purpose of this study is to evaluate what effect, if any, mismatched unrelated volunteer donor and/or haploidentical related donor stem cell transplant may have on severe sickle cell disease

red blood cell transfusions
graft versus host disease
bone marrow transplant
diamond-blackfan anemia
  • 15 May, 2022
  • 1 location