Sickle Cell Disease Clinical Trials

A listing of Sickle Cell Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 220 clinical trials
Sleep Apnea in Sickle Cell Disease (DREPAPNEE)

pathophysiological mechanisms are scarce. OSA is one of the most common conditions responsible for hemoglobin desaturation. The nocturnal hemoglobin desaturation occurring in some sickle cell disease (SCD) patients

vaso-occlusive crisis
blood transfusion
sickle hemoglobin
hemoglobin s
sickle cell trait
  • 10 views
  • 01 Feb, 2022
  • 3 locations
Imatinib for Pain in Sickle Cell Anemia (IMPACT)

phosphorylation and the abundances of RBC-derived microparticles in their blood. In addition, the patients will be monitored for symptoms of sickle cell disease (SCD). The investigators expect band 3 tyrosine

acute chest syndrome
thalassemia
opiates
opioid
absolute neutrophil count
  • 0 views
  • 26 Jan, 2022
  • 2 locations
Telemedicine for Children With Sickle Cell Disease

The purpose of this study is to learn more about how the use of two different types of telemedicine (distance medical care) can address barriers to receiving comprehensive sickle cell care, and whether care can be improved. Aim 1: Adapt two telemedicine models (i.e., hub-and-spoke; direct-to-consumer) for use with children …

  • 0 views
  • 06 May, 2022
  • 1 location
L-Glutamine Therapy for Sickle Cell Anemia

This is a study to determine the efficacy of L-glutamine as therapy for sickle cell anemia and sickle O-thalassemia.

glutamine
thalassemia
anemia
  • 86 views
  • 07 Nov, 2020
  • 1 location
Sleep and Pain in Sickle Cell Disease

This is a study testing the effects of behavioral sleep interventions on pain and brain function in sickle cell disease.

hemoglobinopathy
behavioral symptoms
thalassemia
sleep problem
insomnia
  • 36 views
  • 15 Jun, 2022
  • 1 location
Defibrotide in Sickle Cell Disease-Related Acute Chest Syndrome

This study evaluates the safety of defibrotide in subjects with sickle cell disease (SCD)-associated acute chest syndrome (ACS).

chest x-ray
cough
acute chest syndrome
thalassemia
sickle hemoglobin
  • 1 views
  • 26 Feb, 2022
  • 1 location
Topical Sodium Nitrite in Sickle Cell Disease and Leg Ulcers

patients with sickle cell disease and chronic leg ulcers and to determine its effectiveness in accelerating the healing process and decreasing the pain associated with ulceration. Potential benefit

nitric oxide
nitrite
thalassemia
leg ulcer
  • 33 views
  • 26 Apr, 2022
  • 2 locations
Stem Cell Gene Therapy for Sickle Cell Disease

This Phase I clinical trial will assess the safety and initial evidence for efficacy of an autologous transplant of lentiviral vector modified peripheral blood for adults with severe sickle cell

gene therapy
  • 0 views
  • 20 Apr, 2022
  • 1 location
TMLI and Alemtuzumab for Treatment of Sickle Cell Disease

This phase I trial tests the safety and effectiveness of total marrow and lymphoid irradiation (TMLI) and alemtuzumab as a conditioning regimen in patients with sickle cell disease. Conditioning

acute chest syndrome
alemtuzumab
chest syndrome
asthma
priapism
  • 0 views
  • 16 Jun, 2022
  • 1 location
Reduced Intensity Transplantation for Severe Sickle Cell Disease

children and young adults with Sickle Cell Disease (SCD). Patients less than or equal to 25 years old with SCD who would likely benefit from allogeneic hematopoietic cell transplantation (HCT) will be

acute chest syndrome
alemtuzumab
opiates
cerebral blood flow
splenic sequestration
  • 0 views
  • 29 May, 2022
  • 1 location