Sickle Cell Disease Clinical Trials

A listing of Sickle Cell Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 298 clinical trials
Cholinergic Mechanisms of Attention in Aging

This study will use an anticholinergic pharmacological probe to examine attention network function in SCD using EEG. The overall hypothesis is that in older adults with SCD, normal cognitive

Accepts healthy volunteers
  • 20 Jun, 2022
  • 1 location
Intravenous Gammaglobulin for Sickle Cell Pain Crises

The purpose of this study is to determine whether intravenous immune globulin is safe and effective in the acute treatment of pain crises in sickle cell disease.

  • 07 Nov, 2020
  • 1 location
A Study to Evaluate the Safety and Efficacy of Crizanlizumab in Sickle Cell Disease Related Priapism (SPARTAN)

The goal of the study is to evaluate the efficacy and safety of crizanlizumab in SCD patients with priapism.

  • 15 Feb, 2022
  • 18 locations
A Trial for Prevention of Recurrent Ischemic Priapism in Men With Sickle Cell Disease: A Pilot Study (PIN)

To conduct a randomized controlled internal pilot feasibility trial for the prevention of recurrent ischemic priapism referred to as the Priapism in Nigeria (PIN) trial. The study team will enroll a minimum of 30 participants and a maximum of 200 participants. Study investigators hypothesize that hydroxyurea therapy combined with tadalafil …

  • 29 Apr, 2022
  • 1 location
To Assess the Efficacy and Safety of SCD-044 in the Treatment of Moderate to Severe Atopic Dermatitis

This is a Phase II, randomized, double-blind, placebo-controlled study in subjects with moderate to severe atopic dermatitis.

  • 15 Mar, 2022
  • 9 locations
RH Genotype Matched RBC Transfusions (RBC)

To determine the feasibility of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.

  • 01 Mar, 2022
  • 1 location
The Impact of Oxidative Stress on Erythrocyte Biology (RBC Survival)

This study will address if red blood cells transfused to a sickle cell patient from a donor with a glucose-6-phosphate-dehydrogenase (G6PD) enzyme deficiency have a different lifespan as measured by the percentage of red blood cells that survive post-transfusion compared to red blood cells transfused to a sickle cell patient …

  • 10 Mar, 2022
  • 1 location
Clinical and Biological Effects of Citrus-phytochemicals in Subjective Cognitive Decline.

Subjective cognitive decline (SCD) is receiving increasing attention as a risk factor for incident dementia due to AD. SCD manifests prior to the onset of clinical impairment, and as such could

  • 10 May, 2021
  • 1 location
Impact of a Cognitive Intervention Enriched With Leisure Activities in Persons With Subjective Cognitive Decline

activities. This will be done with a partially randomized controlled double-blind preference trial with a comprehensive cohort design, in participants with subjective cognitive decline (SCD) recruited in

  • 05 Feb, 2021
  • 2 locations
Senicapoc and Dehydrated Stomatocytosis

(KCNN4) channel or the mechanosensitive channel PIEZO1. Senicapoc is a selective blocker of the Gardos channel that has been extensively studied in sickle cell disease and shown to be safe with limited

  • 13 Jun, 2021
  • 1 location