Sickle Cell Disease Clinical Trials

A listing of Sickle Cell Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 55 clinical trials
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce

hydroxyurea
blood test
campath
x-rays
Accepts healthy volunteers
  • 2 views
  • 17 Jun, 2022
  • 1 location
Red Cell Half Life Determination in Patients With and Without Sickle Cell Disease

Background Sickle cell disease (SCD) is an inherited blood disorder. It results from a single genetic change (mutation) in red blood cells (RBCs). RBCs are the

Accepts healthy volunteers
blood disorder
bone marrow transplant
hemoglobin s
sickle cell trait
  • 0 views
  • 14 Jun, 2022
  • 1 location
Glutamine Role in Preventing Vaso-occlusive Crisis Among SCD Patients (Glu_SCD_Egy)

Prospective phase IV interventional open label randomized controlled trial to assess safety and efficacy of glutamine in preventing vaso-occlusive crisis (VOC) episodes in sickle cell pediatrics and adolescents' patients

glutamine
hydroxyurea
electrophoresis
blood transfusion
vaso-occlusive crisis
  • 0 views
  • 27 Jun, 2022
  • 2 locations
A Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab as Adjunct Treatment in Prevention of Vaso-Occlusive Episodes (VOE) in Sickle Cell Disease (SCD) (CROSSWALK-c)

This study is designed to evaluate the efficacy, safety and pharmacokinetics of crovalimab compared with placebo as adjunct therapy in the prevention of VOEs in participants with SCD.

thalassemia
  • 0 views
  • 27 Jun, 2022
  • 2 locations
Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels

Background Sickle cell disease can often be treated with blood stem cell transplants. But for some people the disease returns. This study will give a second

blood test
acute chest syndrome
thalassemia
g-csf
sickle cell trait
  • 12 views
  • 14 Jun, 2022
  • 1 location
Pulmonary Ultrasound in the Diagnosis of Acute Thoracic Syndrome in Vaso-occlusive Sickle Cell Crisis (ECHO-STA)

ATS (acute thoracic syndrome) refers to acute pulmonary involvement in a sickle cell patient. The diagnosis is based on the association of clinical signs (fever or respiratory symptoms) with a recent pulmonary infiltrate on the chest x-ray. The main objective of the study is to evaluate the place of the …

  • 0 views
  • 04 Jun, 2022
  • 1 location
Desmopressin for Bedwetting in Children With SCD

This study assesses if using the medication desmopressin will decrease nightime bedwetting in children with sickle cell disease.

nocturnal enuresis
hemoglobin s
thal
desmopressin
  • 1 views
  • 19 Jun, 2022
  • 1 location
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Long-term Mitapivat Dosing in Subjects With Stable Sickle Cell Disease: An Extension of a Phase I Pilot Study of Mitapivat

Background Sickle cell disease (SCD) is a disorder that causes episodes of acute pain and progressive organ damage. Ways to manage SCD have evolved slowly

acute pain
hemolysis
blood transfusion
glomerular filtration rate
absolute neutrophil count
  • 0 views
  • 18 Jun, 2022
  • 1 location
Intravenous Gammaglobulin for Sickle Cell Pain Crises

The purpose of this study is to determine whether intravenous immune globulin is safe and effective in the acute treatment of pain crises in sickle cell disease. Funding Source: Food and

acute pain
narcotics
thalassemia
  • 21 views
  • 20 Jun, 2022
  • 1 location
Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias

People with severe congenital anemias, such as sickle cell anemia and beta-thalassemia, have been cured with bone marrow transplantation (BMT). The procedure, however, is limited to children

alemtuzumab
osteonecrosis
hydroxyurea
asthma
acute chest syndrome
  • 95 views
  • 18 Jun, 2022
  • 1 location