Melanoma Clinical Trials

A listing of Melanoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 261 clinical trials
Proton Pencil Beam Scanning GRID for Treatment of Bulky Tumors (ProGRID)

This is a single arm, phase I study, evaluating the feasibility, toxicity, and degree of tumor response after novel proton pencil beam scanning (PBS GRID) treatment in patients with bulky tumors that are difficult to manage.

ct scan
cancer
  • 0 views
  • 29 Apr, 2022
  • 1 location
A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of KIN-2787 in adults with BRAF/NRAS-mutated advanced or metastatic solid tumors.

braf inhibitor
BRAF
NRAS
cancer
  • 0 views
  • 10 May, 2022
  • 7 locations
A Study of CM24 in Combination With Nivolumab in Adults With Advanced Solid Tumors

This is an open-label, multicenter, multi-dose escalation and dose expansion study in subjects with selected advanced solid tumors (Part A), advanced recurrent immune checkpoint refractory non-small cell lung cancer (NSCLC) (Part B), and metastatic pancreatic cancer (Part C) to evaluate the safety and tolerability of CM-24 in combination with nivolumab. …

brain metastases
measurable disease
lung carcinoma
pancreatic adenocarcinoma
metastatic pancreatic adenocarcinoma
  • 9 views
  • 12 May, 2022
  • 6 locations
Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor to People With CD70 Expressing Cancers

Background In a new cancer therapy, researchers take a person s blood, select a certain white blood cell to grow in the lab, and then change the genes of these cells using a virus. The cells are then given back to the person. This is called gene transfer. For this …

brain metastases
immunohistochemistry
leukapheresis
metastasis
platelet count
  • 70 views
  • 13 May, 2022
  • 1 location
ADP-A2M4CD8 as Monotherapy or in Combination With Nivolumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)

indications include endometrial, esophageal, esophagogastric junction (EGJ), gastric, head and neck, melanoma, non-small cell lung (NSCLC), ovarian or urothelial cancer.

hla-a
leukapheresis
esophageal cancer
ovarian cancer
measurable disease
  • 14 views
  • 10 May, 2022
  • 14 locations
Open-Label Proof of Concept Study of LTX-315 in Basal Cell Carcinoma

This is a 3-part, open-label, multicenter, dose-escalation, proof-of-concept study with a safety run-in designed to assess the safety, tolerability, MTD, and objective antitumor efficacy of ascending dose strengths of LTX 315 when administered intratumorally to adults with biopsy proven basal cell carcinoma (BCC). The study is expected to enroll approximately …

carcinoma
  • 0 views
  • 23 Apr, 2022
  • 2 locations
A Study to Test How BI 765063 is Taken up in Tumours of People With Different Types of Advanced Cancer Who Are Also Taking Ezabenlimab

This study is open to adults with advanced head and neck cancer, skin cancer, or non-small cell lung cancer. People can take part if previous treatments were not successful. The purpose of this study is to find out how a medicine called BI 765063 is taken up in the tumours …

lung cancer
carcinoma
cancer
measurable disease
squamous cell carcinoma
  • 0 views
  • 16 May, 2022
  • 1 location
A Study of E7386 in Combination With Pembrolizumab in Previously Treated Participants With Selected Solid Tumors

in combination with pembrolizumab in participants with previously treated selected solid tumors (melanoma, colorectal cancer [CRC], hepatocellular carcinoma [HCC]) according to Response Evaluation

measurable disease
systemic therapy
immunomodulators
immunologic adjuvant
BRAF
  • 0 views
  • 12 May, 2022
  • 3 locations
Microbiota Transplant to Cancer Patients Who Have Failed Immunotherapy Using Faeces From Clinical Responders (MITRIC)

This is a single-arm, single-center, open-label, phase IIa study evaluating the safety, feasibility and efficacy of Faecal Microbiota Transplant (FMT) to cancer patients not responding to ICI therapy, using ICI-responders as donors.

serum bilirubin
neutrophil count
programmed cell death 1 ligand 1
platelet count
measurable disease
  • 0 views
  • 07 Apr, 2022
  • 1 location
Communicating With Patients on Cancer Resistance to Treatment: the Development of a Communication Tool. (HECTOR)

Resistance to treatment is one of the major themes in cancer research. Despite this, the definition and clinical implications of resistance to treatment remain under-explored, and patient-physician communication in this context still constitutes a challenge. When resistance to cancer treatments occurs, physicians not only have to explain to the patient …

  • 0 views
  • 24 Apr, 2022
  • 1 location