Hypercholesterolemia Clinical Trials

A listing of Hypercholesterolemia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 37 clinical trials
Featured trial
A randomized, double-blind, placebo-controlled multicenter trial, assessing the impact of inclisiran on major adverse cardiovascular events in participants with established cardiovascular disease

We are seeking participants for a clinical research study who have Atherosclerotic Cardiovascular Disease (thickening/hardening of the arteries which is caused by a buildup of plaque in the lining of an artery).This study is designed to evaluate the treatment of an investigational medication along with a well-tolerated statin therapy (lipid …

atherosclerotic cardiovascular disease
hmg-coa reductase inhibitor
  • 29 Apr, 2022
  • 1 location
Efficacy and Safety of Lomitapide in Paediatric Patients With Homozygous Familial Hypercholesterolaemia (HoFH)

This is a single arm, open label, multi centre phase III study to evaluate the efficacy and long term safety of lomitapide in paediatric patients with HoFH receiving stable LLT (including LA, when applicable) comprising of the following phases: Screening Period (starting at Week 12, i.e. ≤12 weeks prior to …

  • 26 Apr, 2022
  • 10 locations
Coronary and Heart Effects of Early Treatment in Familial Hypercholesterolemia (CHEETAH)

This study evaluates plaque burden and characteristics in early-treated FH patients compared to late-treated FH patients and healthy individuals.

Accepts healthy volunteers
  • 10 May, 2022
  • 1 location
Study of ARO-ANG3 in Participants With Homozygous Familial Hypercholesterolemia (HOFH) (Gateway)

Participants with documented homozygous familial hypercholesterolemia (HoFH) who have provided informed consent will receive 2 open-label doses of ARO-ANG3 and be evaluated for safety and

  • 06 May, 2022
  • 1 location
A Study to Evaluate the Efficacy and Safety of JS002 in Patients With Heterozygous Familial Hypercholesterolemia (HeFH).

heterozygous familial hypercholesterolemia (HeFH). Objective To evaluate the efficacy and safety of JS002 150 mg (Q2W) and 450 mg (Q4W) subcutaneous injection (SC).

  • 29 Apr, 2022
Citrulline Efficacy to Improve Carbohydrate Metabolism Abnormalities in the Patient Treated With High Doses of Statin (STATIMPROVE)

Hypercholesterolemia is a major cardiovascular risk factor. Statins are the first-line drug treatment for hypercholesterolemia and have been shown to be effective in both primary and secondary

  • 13 Apr, 2022
  • 1 location
Efficacy of Clopidogrel on Incidence of Silent Brain Infarction (ECISBI)

Silent brain infarctions (SBIs) are a manifestation of covert cerebrovascular disease, without obvious clinical deficit, noted very often in patients presenting with a new stroke or new transient ischemic attack. SBIs are linked to a significant increase in risk for subsequent stroke and cognitive decline. However, no biomarker is currently …

  • 22 Apr, 2022
  • 1 location
Technology-Assisted Cholesterol Trial in Consumers (TACTiC) (TACTiC)

The purpose of this AUS is to evaluate the extent to which participants can safely and effectively self-select, purchase, and use Crestor OTC 5 mg for a 6-month period according to the label.

  • 16 May, 2022
  • 1 location
A Study of the Efficacy and Safety of MK-0616 (Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-008)

hypercholesterolemia. The primary hypothesis is that at least one of the four doses of MK-0616 tested in this study is superior to placebo on percent change from baseline in LDL-C at Week 8.

cardiovascular disease
cholesterol measurement
lipoprotein cholesterol
  • 13 May, 2022
  • 36 locations
  • 14 May, 2022
  • 14 locations