Hemophilia Clinical Trials

A listing of Hemophilia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 93 clinical trials
Impact of Therapeutic Patient Education on the Toxicity of Immune Checkpoint Inhibitors in Oncology (EDHITO)

The aim of this therapeutic education program is to reduce the apparition of immune-related Adverse Event with patients treated with ICI

carcinoma
cancer
kidney cancer
  • 0 views
  • 28 Feb, 2022
  • 1 location
The Effect of Donation Frequency on Donor Health in Blood Donors Donating Plasma by Plasmapheresis

This project is a randomized controlled non-inferiority study that aims to cover knowledge gaps about the composition and development of plasma proteins, inflammation markers and mental health in Norwegian, voluntary, and unpaid blood donors who donate plasma and blood. We will include 120 male blood donors who are randomized into …

Accepts healthy volunteers
  • 10 views
  • 13 Mar, 2022
  • 1 location
Prevent Postpartum Hemorrhage in Women With Von Willebrand Disease: The VWD-WOMAN Trial

This is a single-center randomized phase III clinical trial, the VWD-Woman Trial, in which 20 pregnant subjects with von Willebrand disease (VWD), defined as VWF ristocetin co-factor activity (VWF:RCo) <0.50 IU/ml (historic) and previous history of bleeding are enrolled. Subjects will include women with VWD age 18 years and older, …

bleeding tendency
hysterectomy
fibrinogen
tranexamic acid
haemostasis
  • 0 views
  • 21 Jul, 2022
  • 1 location
To Assess the Pharmacokinetics and Safety and Tolerability of Efanesoctocog Alfa (BIVV001)in Adults With Type 2N and 3 Von Willebrand Disease (VWD)

Primary Objective: -To characterize the pharmacokinetics (PK) of BIVV001 after a single intravenous (IV) administration, as assessed by factor VIII (FVIII) activity determined by the one-stage activated partial thromboplastin time (aPPT) clotting assay, as well as, BIVV001 capture chromogenic Coatest FVIII activity assay Secondary Objective: -To assess the safety and …

bleeding tendency
coagulation factor
aptt
type 3 vwd
Factor VIII
  • 0 views
  • 11 Jul, 2022
  • 4 locations
To Assess the Pharmacokinetics and Safety and Tolerability of Efanesoctocog Alfa (BIVV001)in Adults With Type 2N and 3 Von Willebrand Disease (VWD)

Primary Objective: -To characterize the pharmacokinetics (PK) of BIVV001 after a single intravenous (IV) administration, as assessed by factor VIII (FVIII) activity determined by the one-stage activated partial thromboplastin time (aPPT) clotting assay, as well as, BIVV001 capture chromogenic Coatest FVIII activity assay Secondary Objective: -To assess the safety and …

bleeding tendency
coagulation factor
type 3 vwd
aptt
Factor VIII
  • 139 views
  • 08 Jul, 2022
  • 4 locations
Safety, Tolerability and Pharmacokinetics Study of KPG-818 in Hematological Malignancies Subjects

This is a Phase 1, multicenter, open-label, multiple-ascending dose study to evaluate the safety, PK, and preliminary clinical activity of KPG-818 in combination with dexamethasone in adult subjects with multiple myeloma (MM), and KPG-818 as monotherapy in subjects with other selected hematological malignancies, including mantle cell lymphoma (MCL), diffuse large …

experimental drug
chronic lymphocytic leukemia
corticosteroids
bone marrow transplant
cancer
  • 0 views
  • 21 Jul, 2022
  • 8 locations
Hydroxyurea Optimization Through Precision Study (HOPS)

Hydroxyurea Optimization through Precision Study (HOPS) is a prospective, multi-center, randomized trial that will directly compare a novel, individualized dosing strategy of hydroxyurea to standard weight-based dosing for children with SCA. The primary objective of the study is to evaluate whether a pharmacokinetics-based starting hydroxyurea dose thieves superior fetal hemoglobin …

hemoglobin f
sickle hemoglobin
thalassemia
anemia
hydroxyurea
  • 82 views
  • 10 Feb, 2022
  • 12 locations
Swiss Hemophilia Registry

The Swiss Hemophilia Registry will collect data on the prophylactic and therapeutic use of factor concentrates in patients with hemophilia and other severe bleeding disorders in Switzerland.

  • 39 views
  • 09 May, 2021
  • 28 locations
Genotype and Phenotype Correlation in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome)

Hereditary thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome) is a rare disorder characterized by thrombocytopenia as a result of platelet consumption, microangiopathic hemolytic anemia, occlusion of the microvasculature with von Willebrand factor-platelet-thrombic and ischemic end organ damage. The underlying patho-mechanism is a severe congenital ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type …

  • 127 views
  • 27 Jan, 2021
  • 7 locations
Study of Individuals Affected With Hypoplasminogenemia (HISTORY)

This is an Investigator initiated retrospective and prospective single cohort study. The study will utilize an international registry and develop a specimen biobank to provide an improved understanding of the natural history of hyposplasminogenemia, to elucidate the heterogeneity of phenotypic expression, identify markers to predict disease course, and inform improved …

  • 0 views
  • 12 May, 2022
  • 10 locations