Chronic Obstructive Pulmonary Disease (COPD) Clinical Trials

A listing of Chronic Obstructive Pulmonary Disease (COPD) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 402 clinical trials
Early COPD for China Pulmonary Health Study Stage II

Discovery of the pathogenesis and targets in the progression of early chronic obstructive pulmonary disease

  • 06 Sep, 2021
  • 6 locations
ICU Predictive Score of WEaning Success in Patients At Risk of Extubation Failure

Observational study in two medical-surgical intensive care units of the Clermont-Ferrand University Hospital to develop a composite score for prediction of 72h-extubation failure in patients at risk of extubation failure.

  • 20 Nov, 2021
  • 1 location
Ventilator-associated Injury (VAI) in Chronic Home Mechanical Ventilation

Rationale The pathophysiological changes in respiratory muscle morphology and functioning in patients with end-stage pulmonary disease are not very well known. Furthermore, in COPD, long-term high-intensity NIV is applied without knowing the exact consequences on the lungs and respiratory muscles. Objective: The aims of the study are to get insight …

  • 26 Jan, 2021
  • 1 location
Identification of Autoantigens in EGPA and Severe Eosinophilic Asthma

In this project the investigators will look for auto-antibodies to relevant proteins both in native form and importantly in post-translationally modified forms. Potential modified auto-antigens are eosinophil proteins (analogous to the cytoplasmic neutrophil proteins identified in vasculitides such as Granulomatosis with Polyangiitis (formerly known as Wegener's granulomatosis) and alternatively structural …

  • 29 Jan, 2021
  • 2 locations
MACCE in Hospitalized Patients With Community-acquired Pneumonia

Community-acquired pneumonia is the most common infection leading to hospitalization in intensive care units and the most common cause of death associated with infection disease. Epidemiological studies have shown that respiratory tract infections are associated with an increased risk for the development of acute cardiovascular and cerebrovascular events. This link …

respiratory infection
  • 06 Oct, 2021
  • 1 location
Pre- and Post-treatment Lung Microbiota Metabolome and Immune Signatures at the Site of Disease in Patients With Active Pulmonary Tuberculosis

The diverse microbial communities in different parts of the human body (microbiome) are important for health but understudied in pulmonary tuberculosis (TB), which is the single biggest infectious cause of death in the world. The investigators will study the site-of-disease microbiome (in the lung bronchoalveolar space) in TB cases to …

  • 10 Apr, 2021
  • 3 locations
Tissue Engineering Approaches to Treat COPD

The study is a pilot/laboratory study comparing lung tissue from control participants with tissue from COPD participants with a chronic bronchitis or emphysema phenotypes. Tissue will be characterised mechanically and biochemically. Lung cells, including DASCp63/Krt5 with a possible role in disease pathology, will be isolated, expanded in vitro, characterised, and …

  • 15 May, 2021
  • 1 location
Reliability and Validity of The '6 Minute Pegboard and Ring Test' in Patients With Breast Cancer

Breast cancer is one of the most common cancers among women in the world and its incidence reaches up to 16%.Although survival can be increased with early diagnosis and more effective therapies, physical complications such as lymphedema, upper extremity dysfunction and chronic pain are frequently seen during and/or after breast …

  • 06 May, 2022
  • 1 location
Validation of the Risk Stratification Score in Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is characterized by a poor prognosis, with a progressive decline in lung function and a considerable variability in the disease's natural history. Besides lung transplantation (LTx), the only available treatments are anti-fibrosing drugs, which have shown to slower the disease course. Therefore, predicting the prognosis is …

lung transplant
diffusion capacity of the lung for carbon monoxide
idiopathic pulmonary fibrosis
  • 25 Nov, 2021
  • 2 locations
Endobronchial Valves Positioning Effects On Diaphragm Function In Patients With Lung Hyperinflation (EVELHYN)

This prospective study aims at evaluating diaphragmatic function before and after endobronchial valves positioning in a COPD patients with lung hyperinflation.

  • 06 Apr, 2022
  • 1 location