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Thymomas Clinical Trials

A listing of Thymomas medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (18) clinical trials

Pembrolizumab and Epacadostat in Patients With Thymic Carcinoma

The amended phase II study of pembrolizumab and epacadostat is for thymic carcinoma patients who recurred after at least one prior chemotherapy regimen. The primary endpoint is response rate; secondary endpoints are Progression-Free Survival, Overall Survival and treatment tolerability. Responses will be assessed according to RECIST 1.1; progression-free survival is ...

Phase

Study of Patients With Non-Small Cell Lung Cancer Esophageal Cancer Malignant Pleural Mesothelioma Mediastinal or Chest Wall Neoplasms or Lung Metastases From Cancers of Non-Thoracic Origin

OBJECTIVES: - Evaluate patients referred to the Thoracic Oncology Section of the Surgery Branch, NCI in order to identify patients who are suitable candidates for clinical research protocols. - Obtain biopsies during staging studies of tumor and adjacent normal tissues as well as serum and urine samples from patients with ...

Phase N/A

Methoxyamine Cisplatin and Pemetrexed Disodium in Treating Patients With Advanced Solid Tumors or Mesothelioma That Cannot Be Removed by Surgery or Mesothelioma That Is Refractory to Pemetrexed Disodium and Cisplatin or Carboplatin

PRIMARY OBJECTIVES: I. To determine the maximum tolerated dose (MTD) and the recommended phase 2 dose (RP2D) for the combination of TRC102 (methoxyamine) with pemetrexed (pemetrexed disodium) and cisplatin in patients with advanced solid tumors. (Arm A) II. To describe the toxicities of TRC102 combined with pemetrexed and cisplatin at ...

Phase

Feasibility Trial of Pembrolizumab in Unresectable Thymoma and Thymic Carcinoma

Study Groups: If you are found to be eligible to take part in this study, you will be assigned to a study group based on when you join this study. Up to 6 participants will be enrolled in Part 1 of the study, and up to 24 participants will be ...

Phase

Confocal Laser Endomicroscopy in Pleural Malignancies

Novel optical imaging techniques such as confocal laser endomicroscopy (CLE) have emerged in recent years as techniques that actually enable in vivo real-time microscopic analysis of malignancies of the GI-tract and lung cancer. Through recent advances the probe became small enough to fit through a biopsy needle and can be ...

Phase N/A

Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer Small Cell Lung Cancer and Thymic Malignancies

BACKGROUND A better understanding of the genetic make-up of the individual tumor may offer potentially improved therapies. This approach may also give rapid access to response data in patients with sometimes rare genetic abnormalities. In addition, it will allow us to test targeted therapies in a select population of patients ...

Phase

Postoperative Conformal Radiotherapy for Stage II-III B Type Thymoma

The role of postoperative radiotherapy in thymoma is controversial. Some retrospective studies were for the radiotherapy, but others were against. However, more inherent biases existed in these trials. Resection, Masaoka stage and pathology were widely accepted as the prognostic factors for thymoma. Furthermore, the frequency of local failure after radical ...

Phase

Study of Chemoradiotherapy for Inoperable Locally Advanced (Stage / a) Thymoma or Thymic Carcinoma

Complete resection is difficult to achieve without damaging the main organs in some locally advanced thymoma or thymic carcinoma. The previous trials have showed that radiotherapy was significantly associated with prolonged OS and chemotherapy is playing an increasing role in treatment of patients with advanced thymoma or thymic carcinoma. However, ...

Phase

Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma

Background Malignant mesothelioma is a malignancy arising from the mesothelial cells of the pleura, peritoneum, pericardium, or tunica vaginalis. Mesothelioma accounts for 0.10% of deaths annually in the United States. Malignant pleural mesothelioma is the most common of these, comprising of 80% of the cases with an annual incidence of ...

Phase N/A

Genomic Profiling of Nodular Thyroid Disease and Thyroid Cancer

This is an open-ended prospective registry. The patients who were diagnosed with thyroid nodules will have a complete clinical and US evaluation. Thyroid nodule biopsy indication and FNA vs core biopsy choices will be made entirely on the clinical grounds, by the managing physicians. Thyroid nodule biopsies may be performed ...

Phase N/A