Congenital Skin Diseases Clinical Trials

A listing of Congenital Skin Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 77 clinical trials
Pyrotinib Plus Vinorelbine in Participants With HER2-positive Previously Treated Locally Advanced or Metastatic Breast Cancer

The purpose of this study is to identify the highest tolerable dose of pyrotinib in combination with vinorelbine and to assess the safety and efficacy of the combination in Patients With HER2-Positive Locally Advanced or Metastatic Breast Cancer. The study will be conducted in two parts. In the first part, …

invasive breast cancer
mammogram
HER2
trastuzumab
erbb2
  • 0 views
  • 14 May, 2022
  • 1 location
Aesthetic Effect of Steri-Strip Orientation on Healing and Scar Appearance in Breast Surgery

All patients undergoing breast biopsy, lumpectomy, needle-localization-guided breast biopsy, and mastectomy at Einstein Medical Center Philadelphia, Einstein Medical Center Montgomery, Center One, or Einstein Elkins Park will be offered participation into the study. Patients who have documented allergies to adhesive or tape, patients taking chronic steroids, and patients with documented …

lumpectomy
mastectomy
breast surgery
Accepts healthy volunteers
diabetes
  • 0 views
  • 25 Mar, 2022
  • 2 locations
A Study Investigating the Safety and Tolerability of an Immune Treatment in Cancer Patients With Lesions to the Skin

The purpose of this study is to test the safety and tolerability of 2141-V11 in people who have cancer that does not respond to standard treatment and who have skin lesions (skin tumors) associated with their cancer. The study will also test how the body processes and responds to 2141-V11, …

gilbert's syndrome
skin lesion
skin tumor
metastasis
growth factor
  • 2 views
  • 16 Feb, 2022
  • 1 location
Upfront Autologous HSCT Versus Immunosuppression in Early Diffuse Cutaneous Systemic Sclerosis

HSCT has been implemented in (inter)national treatment guidelines for diffuse cutaneous systemic sclerosis (dcSSc) and is offered in clinical care and reimbursed by national health insurance in several European countries. However, data and specific guidelines on the best timing of HSCT in the course of dcSSc are lacking. In particular, …

g-csf
mycophenolate
MRSS
scleroderma
diffuse cutaneous systemic sclerosis
  • 0 views
  • 18 Dec, 2021
  • 5 locations
A Phase II Study of Anti-PD-1 (MK-3475) Therapy in Patients With Metastatic Inflammatory Breast Cancer (IBC) or Non-IBC Triple Negative Breast Cancer (TNBC) Who Have Achieved Clinical Response or Stable Disease to Prior Chemotherapy

This phase II trial studies how well pembrolizumab works in treating patients with stage IV inflammatory breast cancer or triple-negative breast cancer that has spread to other places in the body (metastatic) or has come back (recurrent), and who have achieved clinical response or stable disease to prior chemotherapy. Immunotherapy …

progesterone
pleural effusion
edema
liver metastasis
measurable disease
  • 32 views
  • 16 Sep, 2022
  • 1 location
A Study of RC48-ADC Administered Intravenously to Patients With HER2-Positive Metastatic Breast Cancer With or Without Liver Metastases

This is a randomized, open, parallel-controlled, multicenter, phase II/III, seamless design clinical trial to compare the efficacy and safety of RC48-ADC with capecitabine + lapatinib in locally advanced or metastatic human epidermal growth factor receptor 2 (HER2) positive breast cancer and HER2-positive advanced breast cancer with liver metastasis.

invasive breast cancer
lapatinib
her1
measurable disease
breast cancer
  • 137 views
  • 10 Mar, 2022
  • 67 locations
Effects of Treatments on the Microbiome in Healthy Volunteers and Patients With Atopic Dermatitis

Background Atopic dermatitis, or eczema, is a chronic skin disorder. Patients sometimes have infections with S. aureus bacteria. Researchers want to study how eczema treatments affect the number and the type of bacteria on the skin. Objectives To study the effect of eczema treatments on skin bacteria. Eligibility Individuals between …

s. aureus
crust
cephalexin
antibiotic therapy
skin disorder
  • 300 views
  • 18 Sep, 2022
  • 1 location
Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension

The purpose of this phase 2 multicenter, randomized, double-blind, placebo-controlled, study is to assess the safety and efficacy of ifetroban in patients with diffuse cutaneous systemic SSc (dcSSc) or SSc-associated pulmonary arterial hypertension (SSc-PAH).

systemic sclerosis
pulmonary arterial hypertension
rheumatism
diffuse cutaneous systemic sclerosis
ifetroban
  • 0 views
  • 15 Jul, 2022
  • 11 locations
Mechanisms of Action of Photo(Chemo)Therapy in Skin Diseases

The molecular mechanisms of action of photo(chemo)therapy in skin diseases are investigated in this study. The phototherapeutic modalities employed include UVB (ultraviolet B), UVA (ultraviolet A), PUVA (psoralen+UVA) and/or extracorporeal photochemotherapy (photopheresis). The study will address whether and how photo(chemo)therapy affects specific biologic pathways in different skin disorders and search …

extracorporeal photopheresis
psoralen
chemotherapy regimen
skin disorder
puva
  • 248 views
  • 21 Jan, 2021
  • 1 location
Autologous Stem Cell Transplantation With CD34-Selected Peripheral Blood Stem Cells (PBSC) in Patients With Treatment Resistant Systemic Sclerosis (SSc) (SSc)

The purpose of this study is to determine whether a regimen of high-dose immunoablative therapy will demonstrate safety that is consistent or improved with other published regimens in SSc patients, while maintaining a treatment effect.

fibrosis
systemic sclerosis
prednisone
ct scan
rituximab
  • 216 views
  • 20 Sep, 2022
  • 2 locations