Congenital Skin Diseases Clinical Trials

A listing of Congenital Skin Diseases medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 76 clinical trials
Subcutaneous Injections of Autologous ASC to Heal Digital Ulcers in Patients With Scleroderma.

Ischemic digital ulcers (DUs) are a frequent complication in systemic sclerosis with a major impact on hand function and quality of life. Digital injection of autologous cultured adipose-derived stromal constitutes a promising approach to treat scleroderma-induced refractory ischemic DUs where no alternative therapy is validated. The aim of this phase …

scleroderma
digital ulcer
follicle stimulating hormone
progressive systemic sclerosis
  • 0 views
  • 25 Jan, 2021
  • 6 locations
Anastrozole Palbociclib Trastuzumab and Pertuzumab in HR-positive HER2-positive Metastatic Breast

This is a multicenter, phase I/II trial of anastrozole, palbociclib, trastuzumab, and pertuzumab is proposed as first-line therapy in metastatic hormone receptor-positive, HER2-positive breast cancer patients. In this phase I/II clinical trial, the researchers aim to establish the safety and efficacy of dual HER2 therapy in combination with palbociclib and …

ki-67
cancer
palbociclib
pertuzumab
erbb2
  • 38 views
  • 09 Jul, 2021
  • 7 locations
A Randomized, Double-Blind, Placebo-Controlled Study of Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis

This is a 52 week, single center, randomized, double-blind, placebo-controlled study. After patients maintain a stable dose of Mycophenolate Mofetil (MMF) for at least 1 month, they will be randomized to treatment with either Belimumab & Rituximab or placebo.Patients in both groups will be on background MMF for the entirety …

cancer
diffuse cutaneous systemic sclerosis
raynaud's syndrome
lupus
rituximab
  • 29 views
  • 15 Sep, 2022
  • 1 location
Exercise Capacity of Patients With Dermatomyosis

Dermatomyositis (DM) patients experience muscle weakness and low aerobic capacities, which are associated with poor health status and increased mortality. The origin of this muscle impairment remains unknown. The investigators hypothesize that mitochondria functioning is impaired in DM muscle and links with exercise capacities.

weakness
myopathy
creatine kinase
muscle biopsy
dermatomyositis
  • 0 views
  • 04 Oct, 2022
  • 1 location
Phase 1 Study of ULSC in Patients With Polymyositis (PM) and Dermatomyositis (DM)

This study will investigate Umbilical Cord Lining Stem Cells (ULSC) as an investigational medicinal product and its use in patients with polymyositis (PM) or dermatomyositis (DM) to see if a single intravenous (IV) infusion of allogeneic umbilical cord lining stem cells (ULSC) safe, tolerable, and feasible to administer.

dermatomyositis
polymyositis
  • 4 views
  • 06 May, 2022
  • 1 location
An Open-label Study of Sodium Thiosulfate for Treatment of Calcinosis Associated With Juvenile and Adult Dermatomyositis

Background Dermatomyositis (DM) and juvenile dermatomyositis (JDM) cause inflammation in the muscles. People with DM and JDM can develop calcium deposits in places they should not, known as calcinosis. Calcinosis can be painful and cause disabilities and other problems. Researchers want to learn more about calcinosis to find treatments for …

calcium
igiv
creatine kinase
urine tests
myositis
  • 190 views
  • 16 Sep, 2022
  • 1 location
Leflunomide in Previously Treated Metastatic Triple Negative Cancers

Triple negative breast cancer (TNBC) represents about 15% of breast cancers and is characterized by the lack of expression of estrogen receptor (ER), progesterone receptor (PR), and HER-2 non-amplification. Women with TNBC tend to be younger, African American, and BRCA-1 germline carriers. The hallmark of this subtype is early metastatic …

cancer
triple negative breast cancer
estrogen receptor
progesterone receptor
erbb2
  • 10 views
  • 16 Jun, 2022
  • 3 locations
Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study (ITS-PILOT)

Ectopic soft tissue calcifications or ossifications can complicate the course of numerous diseases; most of them are rare or very rare. Even if the clinical, radiological and pathological presentation of ectopic calcifications and ossifications are different, the same hypotheses are discussed considering their hypothetical pathophysiology. Indeed, high calcium phosphate product, …

calcium
progressive systemic sclerosis
computerized tomography
parathyroid hormone
dermatomyositis
  • 13 views
  • 24 Mar, 2022
  • 3 locations
PET-MRI for Axillary Staging in Node Negative Breast Cancer Patients

Axillary lymph node status is an important prognostic factor for patients with breast cancer. After breast cancer diagnosis, current nodal staging consists of axillary ultrasound (US) combined with tissue sampling when deemed necessary. In case of positive axillary lymph nodes, patients will undergo axillary lymph node dissection (ALND). In case …

cancer
breast carcinoma
sentinel node
cancer diagnosis
sentinel lymph node biopsy
  • 10 views
  • 09 Jul, 2022
  • 2 locations
Atezolizumab, Cobimetinib, and Eribulin in Treating Patients With Chemotherapy Resistant Metastatic Inflammatory Breast Cancer

This phase II trial studies how well atezolizumab, cobimetinib, and eribulin work in treating patients with inflammatory breast cancer that has spread to other places in the body (metastatic). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the …

cancer
platelet count
cobimetinib
estrogen receptor
erbb2
  • 1 views
  • 31 Jan, 2022
  • 1 location