Hypogammaglobulinemia Clinical Trials

A listing of Hypogammaglobulinemia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 14 clinical trials
Double-blind, Randomized, Placebo-controlled, Prospective Phase III Study Evaluating Efficacy and Safety of Panzyga in Primary Infection Prophylaxis in Patients With Chronic Lymphocytic Leukemia ("PRO-SID" Study)

Study Evaluating Efficacy and Safety of Panzyga in Primary Infection Prophylaxis in Patients with Chronic Lymphocytic Leukemia

primary infection
chronic lymphocytic leukemia
igiv
  • 8 views
  • 10 Jul, 2022
  • 29 locations
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS

Background WHIMS (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis Syndrome) is caused by various genetic changes that increase the activity of the

white blood cell count
cancer
depo-provera
colony stimulating factor
AIDS
  • 112 views
  • 20 Jul, 2022
  • 1 location
Immune Disorder HSCT Protocol

This study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders. A regimen that maximizes host immune suppression is expected to reduce graft rejection and optimize donor cell engraftment.

colony stimulating factor
stem cell transplantation
hsct
stem cell infusion
g-csf
  • 125 views
  • 11 May, 2022
  • 1 location
Analysis of the Immune Parameters of COVID-19 Infection in Patients With Multiple Myeloma

Among all MM patients included in the cohort at the time of diagnosis of SARS-CoV-2 infection, blood samples will be collected at inclusion, at time of the infection acute phase in the most severe cases (when admitted in intensive care units), and at recovery. The following immune function tests will …

  • 0 views
  • 27 Mar, 2021
  • 55 locations
Anti-CD19 CAR in PiggyBac Transposon-Engineered T Cells for Relapsed/Refractory B-cell Lymphoma or B-cell Acute Lymphoblastic Leukemia

Our previous study demonstrated that anti-CD19 chimeric antigen receptor in piggyBac transposon-engineered T cells have strong tumor-killing activity in vitro and therapeutic effects in cell line-derived xenograft models, and no obvious side effects such as neurotoxicity and cytokine storm occurred. Therefore, we want to evaluate the safety and clinical effect …

cancer
multiple myeloma
cancer chemotherapy
leukemia
remission
  • 0 views
  • 22 May, 2021
  • 1 location
Bispecific CD19/CD22 CAR-T for Treatment of Children and Young Adults With r/r B-ALL

The purpose of this study is to evaluate the safety and efficiency of autologous CD19/CD22 CAR-T lymphocytes in a cohort of pediatric and young adult patients with relapsed /refractory B-lineage acute lymphoblastic leukemia

  • 0 views
  • 07 Aug, 2021
  • 1 location
Ocrelizumab VErsus Rituximab Off-Label at the Onset of Relapsing MS Disease (OVERLORD-MS)

This is a multicenter non-inferiority study, designed to establish non-inferiority of the study treatment rituximab compared with the comparator ocrelizumab for consecutively included patients (male or female) with active relapsing-remitting multiple sclerosis aged 18-60 years.

rituximab
brain mri
disease or disorder
MRI
ocrelizumab
  • 0 views
  • 07 Apr, 2022
  • 1 location
Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

Background Allogeneic blood or marrow transplant is when stem cells are taken from one person s blood or bone marrow and given to another person. Researchers think this may help people with immune system problems. Objective To see if allogeneic blood or bone marrow transplant is safe and effective in …

cancer
x-rays
electrocardiogram
mycophenolate mofetil
blood test
  • 511 views
  • 11 Aug, 2022
  • 2 locations
Rituximab-Induced Hypogammaglobulinemia in Multiple Sclerosis

increasingly utilized as an off-label treatment option across MS patients . In addition, there have been increasing reports of rituximab causing hypogammaglobulinaemia and antibody deficiency across a

vaccination
deficiency
rituximab
immunoglobulins
disease or disorder
  • 1 views
  • 28 Feb, 2022
  • 1 location
COVID-19 Vaccine Responses in PIDD Subjects

The goal of our study is to assess the cellular immune responses of participants with antibody deficiency disease before and after immunization with SARS-CoV-2 mRNA vaccines.

replacement therapy
Accepts healthy volunteers
immune globulin
genetic tests
genetic testing
  • 0 views
  • 20 Apr, 2022
  • 3 locations