Cytomegalovirus (CMV) Retinitis Clinical Trials

A listing of Cytomegalovirus (CMV) Retinitis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 23 clinical trials
Viral Specific T-Lymphocytes to Treat Adenovirus, CMV and EBV

The primary purpose of this phase I/II study is to evaluate whether partially matched, ≥2/6 HLA-matched, viral specific T cells have efficacy against adenovirus, CMV, and EBV, in subjects who have previously received any type of allogeneic HCT or solid organ transplant (SOT), or have compromised immunity. Reconstitution of anti-viral …

pneumonia
solid organ transplant
retinitis
dhpg
prednisone
  • 6 views
  • 04 Oct, 2022
  • 1 location
Multi-antigen CMV-Modified Vaccinia Ankara Vaccine in Treating Pediatric Patients With Positive Cytomegalovirus Undergoing Donor Stem Cell Transplant

This phase I/II trial studies the side effects and best dose of multi-antigen cytomegalovirus (CMV)-modified vaccinia ankara vaccine and to see how well it works in treating pediatric patients with positive cytomegalovirus who are undergoing donor stem cell transplant. Multi-antigen CMV-modified vaccinia ankara vaccine may help people resist CMV life-threatening …

stem cell transplantation
HIV Infection
immunosuppressive agents
vaccinia
multi-peptide cmv-modified vaccinia ankara vaccine
  • 2 views
  • 05 Jul, 2022
  • 1 location
Treatment of Cytomegalovirus (CMV) Infections With Viral-Specific T Cells

The present trial will consist of the treatment of 20 pediatric and adult Hematopoietic Stem Cell Transplantation (HSCT) recipients or immunocompromised participants diagnosed with opportunistic Cytomegalovirus (CMV) infections with virus-specific, antigen-selected T-cells. CMV-specific T-cells will be isolated from donor leukapheresis products using the CliniMACS® Prodigy. Prior studies on transfer of …

pneumonia
ganciclovir
foscarnet
valganciclovir
dhpg
  • 41 views
  • 08 Feb, 2022
  • 1 location
Haploidentical Donor CMV Specific CTL to Treat CMV Reactivation or Infection After Solid Organ & HCT

This trial studies the side effects and how well allogeneic cytomegalovirus-specific cytotoxic T lymphocytes (donor cytomegalovirus [CMV] specific cytotoxic T-lymphocytes [CTLs]) works in treating CMV reactivation or infection in participants who have undergone stem cell transplant or solid organ transplant. White blood cells from donors may be able to kill …

ganciclovir
solid organ transplant
valganciclovir
dhpg
cancer
  • 1 views
  • 12 May, 2022
  • 2 locations
Virus Specific Cytotoxic T-Lymphocytes (CTLs) for Refractory Cytomegalovirus (CMV)

CMV cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered in children, adolescents and young adults (CAYA) with refractory cytomegalovirus (CMV) infection post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT), with primary immunodeficiencies (PID) or post solid organ transplant. Funding Source: FDA OOPD

ganciclovir
solid organ transplant
viral therapy
dhpg
immunodeficiency
  • 15 views
  • 07 Oct, 2022
  • 5 locations
CMV Specific T Cell Therapy After Allogeneic Stem Cell Transplantation.

Viral infections remain an important cause of morbidity and mortality after allogeneic stem cell transplantation (SCT), especially after myelo-ablative conditioning and if the donor is antigen-mismatched or haplo-identical.. In the described setting the patient's own immune system has been destroyed by the necessary highly immuno- and myelo-ablative conditioning and all …

ganciclovir
viral therapy
cell transplantation
dhpg
antiviral drugs
  • 47 views
  • 24 Feb, 2022
  • 8 locations
T Cell Therapy of Opportunistic Cytomegalovirus Infection

The purpose of this study is to determine if a specific type of cell-based immunotherapy, using T-cells from a donor that are specific against cytomegalovirus (CMV) is feasible to treat infections by CMV. Adoptive T-cell therapy is an investigational (experimental) therapy that works by using the blood of a donor …

ganciclovir
foscarnet
allogeneic hematopoietic stem cell transplant
valganciclovir
dhpg
  • 81 views
  • 04 Oct, 2022
  • 1 location
CMV-TCR-T Cells for Refractory CMV Infection After HSCT

This is a single centre, single arm, open-label, phase I study to evaluate the safety and effectiveness of CMV-TCR-T cell immunotherapy in treating refractory CMV infection after HSCT.

  • 0 views
  • 29 Oct, 2021
  • 1 location
Association of T Gamma Delta-CD16+ Cells and Anti-CMV Immunoglobulins in the Prevention of CMV Infection

CMV infection in transplantation remains the most frequent infectious complication causing increased morbidity and mortality. International recommendations advocate prevention of this infection by instituting direct antiviral treatment or monitoring viral replication by PCR with the start of curative antiviral treatment when the DNAemia is positive. The risk of CMV infection …

kidney transplant
  • 0 views
  • 26 Nov, 2021
  • 1 location
Viral Infections in Healthy and Immunocompromised Hosts

Background Viral infections are an important cause of illness and death in hospitalized patients as well as outpatients. New strains of viruses may appear and infect both healthy people and those with weak immune systems. A better understanding of these new virus strains (such as SARS-CoV-2, the virus that causes …

Accepts healthy volunteers
immunoglobulin
  • 461 views
  • 07 Oct, 2022
  • 1 location