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Addictions Clinical Trials

A listing of Addictions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (277) clinical trials

Babies Living Safe and Smokefree

The purpose of this randomized controlled trial is to develop and test the efficacy of a multilevel, multimodal intervention designed to reduce children's exposure to secondhand tobacco smoke (primary outcome) and promote smoking cessation in mothers (secondary outcome). Low-income mothers who smoke and their children will be enrolled from the ...

Phase N/A

Pharmacokinetics of Nicotine Sublingual Tablets Versus Nicorette Lozenge in Healthy Smokers

Objective The primary objective of this study is to determine the pharmacokinetic profile of a single dose of Nicotine Sublingual Tablets, 4 mg (Test Product) versus Nicorette Lozenge 4 mg in healthy adult smokers when administered under fasted conditions. Study Design This is an open-label, pseudorandomized, two-way crossover comparison of ...


Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence

Poor medication adherence (a) results in poorer treatment outcome and (b) accounts for $100 to $290 billion in U.S. healthcare costs annually. Therefore, interventions that target medication adherence are increasingly crucial for patient care and cost-effectiveness. Mobile technologies such as smartphones are increasingly ubiquitous and affordable in the U.S., and ...

Phase N/A

Arise: An Online Relapse Prevention Tool for Adolescent Substance Abusers

Purpose: In Phase I of this SBIR project, 3C Institute (3C) developed a working prototype of For Life (henceforth Arise), an innovative computer-based coping skills educational program for adolescent substance abuse treatment completers. For Phase I, 3C developed and tested two customizable intelligent educational modules to teach coping skills in ...


Structured Discontinuation vs Continued Therapy in Suboptimal and Optimal Responders to High-dose Long-term Opioids for Chronic Pain

The purpose of this study is to evaluate the effect on pain intensity (PI) of structured discontinuation of long-term opioid analgesic therapy compared to continuation of opioid therapy in Suboptimal and Optimal Responders to high-dose, long-term opioid analgesic therapy for chronic low back pain (CLBP).


New Approaches to Smoking Cessation in Heavy Drinkers

The purpose of the proposed project is to develop and test a 12-week integrated cognitive-behavioral therapy (CBT) intervention for smoking and alcohol (SA) + varenicline (Chantix) among heavy drinking smokers (i.e., CBT for SA). The project involves two phases. In Phase 1, an open-label pre-pilot study of CBT for SA ...


Prevention of Drug Use in Adolescence: Intervening in Parenting Styles

To investigate whether brief motivational intervention is associated with the change of parenting style in parents of teenagers seeking to prevent drug use among their children.


Electronic Cigarettes and Reactivity to Smoking Cues

Tobacco-related illness causes over 5 million deaths per year in the developed world, and most currently available smoking cessation treatments do not effectively enhance long-term cessation outcomes. Reactivity to smoking cues is one factor associated with relapse vulnerability, which is untreated by cessation aids such as NRT. Combining treatments, which ...

Phase N/A

STAR - Seek Test and Retain. Linkages for Black HIV+ Substance-Using MSM

The HIV epidemic in the United States most severely affects men who have sex with men (MSM): 61% of all new infections occur in this population. Black MSM bear a disproportionate burden, with prevalence of 28%, in contrast to 19% in MSM overall. Black MSM undergo HIV testing less frequently ...

Phase N/A

Enhanced Access to HIV Care for Drug Users in San Juan Puerto Rico

Study Design The overall goal of this project is to implement and evaluate a community-level, structured approach, the "Enhanced HIV Care Access and Retention Intervention" for drug users in San Juan, Puerto Rico. It will bring HIV care directly to five San Juan neighborhoods in which a high proportion of ...

Phase N/A