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Addictions Clinical Trials

A listing of Addictions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (31) clinical trials

AXS-05 Phase II Trial on Smoking Behavior

This study aims to investigate the potential efficacy of a combination of two FDA-approved agents, sustained release (SR) Bupropion (BUP) and immediate release (IR) Dextromethorphan (DXM), for the purpose of smoking cessation treatment. DXM, a widely used over-the-counter cough suppressant, is a nicotine receptor antagonist. In fact, studies by Duke's ...

Phase

Aspirin and Zileuton and Biomarker Expression in Nasal Tissue of Current Smokers

PRIMARY OBJECTIVES: I. To analyze the impact of combined treatment of acetylsalicylic acid (ASA) (aspirin) and zileuton on smoking-related gene expression signature in the nasal epithelium in current smokers and to analyze any difference between the ASA and zileuton intervention and placebo control. SECONDARY OBJECTIVES: I. To assess the impact ...

Phase

Combining Varenicline and Naltrexone for Smoking Cessation

This study is a double-blind, randomized clinical trial using a two group medication design consisting of the combination of VAR (1 mg twice daily) + NTX (50 mg once daily) and VAR (1 mg twice daily) + PLA (matched to NTX), for smoking cessation in a sample of heavy drinking ...

Phase

Methadone Demonstration Project

The problem of Neonatal Abstinence Syndrome (NAS) has reached epidemic proportions in the United Sates and has created challenges for health care providers, burden to the institutions and most importantly lasting repercussions for the infants and the mothers that care for them. For the time frame July 1, 2013 through ...

Phase

Gabapentin for Bipolar & Cannabis Use Disorders

Bipolar disorder (BD) is the Axis I condition most strongly associated with cannabis use disorder (CUD); there is a six-fold increase in the prevalence of CUD in individuals with BD relative to the general population. Individuals with co-occurring CUD and BD (CUD+BD) have substantially worse clinical outcomes than those with ...

Phase

Distress Tolerance Treatment for Substance Users

Despite recent advances in substance abuse interventions, a large percentage of clients entering residential treatment for substance use will drop out of treatment prematurely, and of the remaining, many will relapse soon after treatment completion. Previous research indicates that an individual's ability to withstand psychological distress is a key factor ...

Phase

N-acetylcysteine for Tobacco Use Disorder

The aim of this study is to assess the effects of N-acetylcysteine (NAC) on initial cessation and relapse prevention in adult cigarette smokers. Specifically, this study has the following aims: Aim 1) Examine the efficacy of NAC, compared to placebo, in helping smokers achieve three days of continuous abstinence; Aim ...

Phase

Cannabidiol and Cocaine Craving/Dependence

The investigators will carry out a double-blind, randomized, parallel-group, placebo-controlled trial to assess the effects of 92 days of CBD 400 mg (for the first 2 days starting on Day 2 of the study) or 800 mg (subjects who report side effects with the 800mg dose will be administered the ...

Phase

Bilateral Prefrontal Modulation in Alcoholism

Before (baseline) and after tDCS or sham-tDCS treatment, subjects will be examined: clinically, regarding craving (obsessive compulsive scale), depressive (Hamilton depression rating scale) and anxiety (Hamilton anxiety rating scale) symptoms and quality of life of the World Health Organization (WHOQOL-BREF); cognitively, regarding frontal (Frontal assessment battery), mental state (mini-mental status ...

Phase

Bilateral Prefrontal Modulation in Crack-cocaine Addiction

Before (baseline) and after tDCS or sham-tDCS treatment, subjects will be examined: clinically, regarding craving (obsessive compulsive scale), depressive (Hamilton depression rating scale) and anxiety (Hamilton anxiety rating scale) symptoms and quality of life of the World Health Organization (WHOQOL-BREF); cognitively, regarding frontal (Frontal assessment battery), mental state (mini-mental status ...

Phase