Liver Cancer Clinical Trials

A listing of Liver Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 55 clinical trials
Pembrolizumab After Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver and Who Are Undergoing Liver Surgery

This phase II trials studies how well pembrolizumab and vactosertib work after standard of care chemotherapy in patients with colorectal cancer that has spread to the liver that can be removed by surgery (resectable hepatic metastases). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack …

folfox regimen
growth factor
primary tumor
bevacizumab
liver surgery
  • 4 views
  • 17 Sep, 2021
  • 1 location
Perioperative MVT-5873 a Fully Human Monoclonal Antibody Against a CA 19-9 Epitope for Operable CA 19-9 Producing Pancreatic Cancers Cholangiocarcinomas and Metastatic Colorectal Cancers

Background Gastrointestinal tumors have a molecule called CA19-9 in the tumors and blood. The agent MVT-5873 was designed to block this molecule. Researchers want to test how safe it is to give this agent to people before and after surgery to remove a tumor. They want to learn the highest …

solid tumour
biliary stenting
primary tumor
ca19-9
adenocarcinoma
  • 35 views
  • 12 Sep, 2021
  • 1 location
Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver

Background Many people with colorectal cancer get liver metastases. Standard treatment for this is a combination of chemotherapy drugs. Directing the chemotherapy to the liver may be effective. A device that does this a pump that delivers drugs over 2 weeks at constant rate into the hepatic artery. The person …

systemic chemotherapy
solid tumour
dexamethasone
chemotherapy drug
liver metastasis
  • 91 views
  • 12 Sep, 2021
  • 1 location
Bempegaldesleukin and Pembrolizumab With or Without Chemotherapy in Locally Advanced or Metastatic Solid Tumors

This study is to assess the safety and tolerability, and to assess the preliminary clinical benefit of NKTR-214 when combined with pembrolizumab (KEYTRUDA) with or without chemotherapy. The study is comprised of two groups; dose optimization and dose expansion cohorts. Dose Optimization included first-line and second-line advanced or metastatic solid …

pemetrexed
oximetry
stage iv non-small cell lung cancer
metastatic urothelial carcinoma
ROS1
  • 1684 views
  • 23 Sep, 2021
  • 70 locations
A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies

This is a study to determine the maximum tolerated dose (MTD) for CDX-1140 (CD40 antibody), either alone or in combination with CDX-301 (FLT3L), pembrolizumab, or chemotherapy and to further evaluate its tolerability and efficacy in expansion cohorts once the MTD is determined.

b-cell lymphoma
systemic therapy
adenocarcinoma
cholangiocarcinoma
peritoneal carcinoma
  • 399 views
  • 17 Sep, 2021
  • 11 locations
Phase Ib of L-NMMA and Pembrolizumab

(NSCLC), head and neck squamous cell carcinoma (HNSCC), classical Hodgkin lymphoma (cHL), urothelial carcinoma, Cervical Cancer, Esophageal Cancer, Gastric Cancer, Hepatocellular Carcinoma, Merkel Cell

serum total bilirubin
gonadotropin
ejection fraction
stage iv non-small cell lung cancer
liver metastasis
  • 40 views
  • 15 Sep, 2021
  • 1 location
Study of Safety and Tolerability of BCA101 Alone and in Combination With Pembrolizumab in Patients With EGFR-driven Advanced Solid Tumors

The investigational drug to be studied in this protocol, BCA101, is a first-in-class compound that targets both EGFR with TGF. Based on preclinical data, this bifunctional antibody may exert synergistic activity in patients with EGFR-driven tumors.

head and neck carcinoma
solid tumour
primary tumor
investigational drug
programmed cell death 1 ligand 1
  • 7 views
  • 25 Sep, 2021
  • 6 locations
A Study in Patients With Different Types of Advanced Cancer (Solid Tumors) to Test Different Doses of BI 907828 in Combination With BI 754091 (Ezabenlimab) and 754111 or BI 907828 in Combination With BI 754091 (Ezabenlimab)

, skin cancer, sarcoma, liposarcoma, and liver cancer. The participants get a combination of 3 medicines called BI 907828, BI 754091, and BI 754111. BI 907828 is a so-called MDM2 inhibitor that is being

TP53
EGFR
metastasis
BRAF
liver metastasis
  • 5 views
  • 15 Sep, 2021
  • 4 locations
People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents

Background Chronic hepatitis C infects the liver. It may scar the liver. This is called cirrhosis and may lead to liver cancer or death. Current chronic hepatitis

cancer
ribavirin
antiviral drugs
hcv genotype
fibroscan
  • 18 views
  • 22 Sep, 2021
  • 1 location
A Study of DSP-7888 Dosing Emulsion in Combination With Immune Checkpoint Inhibitors in Adult Patients With Advanced Solid Tumors

This is a Phase 1b/2, open-label, multicenter study of DSP-7888 Dosing Emulsion in combination with checkpoint inhibitors (nivolumab or pembrolizumab) in adult patients with solid tumors, that consists of 2 parts: dose search part of the study (Phase 1b and Phase 1b Enrichment Cohort) and the dose expansion part of …

gm-csf
metastatic gastric cancer
pet scan
liver metastasis
metastatic urothelial carcinoma
  • 59 views
  • 15 Sep, 2021
  • 25 locations