Aging Clinical Trials

This Phase III study is designed as a randomized, double-blinded, placebo-controlled study for subjects with evidence of early AD. The study will evaluate safety and tolerability, efficacy as measured by CDR-SB, and will determine if the combination therapy ALZT-OP1 will slow down, arrests, or reverse cognitive and functional decline in ...

The goal of this study is to find out if acarbose, a medicine commonly used to treat diabetes, may have other effects in the body that could slow the aging process. Laboratory experiments have shown that mice treated with acarbose live longer. Scientists believe that acarbose may have “anti-aging” effects ...

The purpose of this research study is to determine the effect of dietary supplements on muscle protein metabolism. There are 2 to 3 study visits. Two of the visits will be overnight stays in the research unit that will last approximately 24 hours. There will be a medical screening, body ...

The purpose of this project is to develop a questionnaire of self-reported navigation abilities. There are no study visits to Washington University. Participation will take about 10 minutes. Participants will complete a survey online at home and will be entered to win a $50.00 gift card.

Dapagliflozin Effect on Cardiovascular Events A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Effect of Dapagliflozin 10 mg Once Daily on the Incidence of Cardiovascular Death, Myocardial Infarction or Ischemic Stroke in Patients With Type 2 Diabetes Inclusion Criteria: Provision of informed consent prior to any study specific procedures ...

Alzheimer's disease is the most common neurodegenerative disorder and its prevalence steeply increases. The small number of effective treatments for Alzheimer's disease highlights a need for further research into novel therapeutic possibilities. Glutamate-mediated excitotoxicity in neuropsychiatric disorders and in particular in Alzheimer's disease has been shown to cause significant cerebral ...

Purpose of the study: This research seeks to understand how Down syndrome and Alzheimer’s disease may affect a person’s memory and thinking as they get older. The goals of this longitudinal project are: to follow neurological, learning and memory changes in adults with Down syndrome as they age; to examine ...

The purpose of research is to look at how different parts of the human brain are connected and how those connections change as people age.  There are up to 4 study visits. Visits will take 3 to 6 hours each. There will be a 10 to 15 minute phone screen, ...

Aging Frailty – Clinical Research Study

The rrAD study is testing several strategies that may reduce the risk of Alzheimer’s disease in individuals at risk for the disease when compared to usual care. These strategies include: Aerobic exercise Intensive medical management of blood pressure and cholesterol The combination of these two approaches