High Cholesterol (Hyperlipidemia) Clinical Trials

A listing of High Cholesterol (Hyperlipidemia) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 71 clinical trials
Study of Efficacy and Safety of Inclisiran in Japanese Participants With High Cardiovascular Risk and Elevated LDL-C

The aim of the study is to assess the efficacy and safety of inclisiran in Japanese participants with an increased LDL-C concentrations. The study also evaluates the pharmacokinetics of inclisiran in a subset of Japanese participants.

  • 0 views
  • 15 May, 2021
  • 34 locations
Soy Modulation of Immune Activation LDL- Levels and Lowering Inflammation by Pretzel Isoflavone Dietary Intervention

Combination antiretroviral therapy (ART, HIV medications) dramatically increases the expected lifespan of HIV (Human Immunodeficiency Virus)infected patients; yet, the risks for cardiovascular disease (CVD), such as heart attacks and stroke, are increased in this population. This increased risk may be linked to persistent inflammation and activation of the immune system. …

hiv-1 antigen
stroke
antiretroviral therapy
LDL Cholesterol
hiv-1 rna measurement
  • 11 views
  • 03 Mar, 2021
  • 1 location
Effect of Evolocumab on Coronary Artery Plaque Volume and Composition by CCTA and Microcalcification by F18-NaF PET

This study will quantify changes in coronary plaque volumes and plaque composition in patients treated with evolocumab. Previous intravascular ultrasound studies have shown that treatment with a lipid-lowering PCSK9 enzyme inhibitor, such as evolocumab, to be associated with a reduction of the fatty deposits that cause plaque in the arteries, …

acute coronary syndrome
infarct
transient ischemic attack
stroke
hmg-coa reductase inhibitors
  • 6 views
  • 04 Feb, 2021
  • 1 location
Nutritional Transitions to More Plant Proteins and Less Animal Proteins: Understanding the Induced Metabolic Reorientations and Searching for Their Biomarkers (ProVegOmics)

The dietary shift from animal to plant protein sources is one of the key aspects of the nutritional transition towards more sustainable food system and diets. However the metabolic implication of this shift in protein sources are still poorly understood. This project aims to characterize and understand the metabolic orientations …

sugars
fats
  • 7 views
  • 25 Jan, 2021
  • 1 location
PROSPective Evaluation of Fortified Eggs Related to Improvement in The Biomarker Profile for Your Health

The objective of the study is to assess the effect of fortified eggs (compared to a non-egg supplemented diet) and intermittent fasting (IF) (compared to a usual care diet) on biomarker profile at 4 months. This will be a 140-participant, 2x2 factorial, randomized clinical trial comparing fortified eggs vs. a …

  • 0 views
  • 30 Jan, 2021
  • 1 location
The CHORAL Flow Study

CHORAL Flow is a randomised, double blinded, placebo-controlled trial of the effects of evolocumab on coronary flow at 12 weeks.

hmg-coa reductase inhibitors
cholesterol level
statin therapy
atorvastatin
angiography
  • 18 views
  • 24 Jan, 2021
  • 1 location
Plant Sterol INtervention for Cancer Prevention (PINC)

Several types of human cells convert cholesterol into other molecules, including oxysterols. Oxysterols can promote breast cancer growth and help tumours to spread. Some breast cancer types recruit other cells (host cells) able to produce oxysterols within the local cancer environment. How these other cells help breast tumours metastasize or …

metastasis
dietary modification
phytosterol
cancer
sugars
  • 131 views
  • 30 May, 2021
  • 1 location
Cardiovascular Risk Assessment for Patients With Rheumatoid Arthritis Arthritis:

One of the greatest success stories in rheumatology - the achievement of rheumatoid arthritis (RA) remission - is tempered by the fact that individuals with RA are dramatically under evaluated and under treated to reduce the risk for heart attacks and strokes. This project will build the foundation for an …

  • 0 views
  • 03 Feb, 2021
  • 1 location
A Nurse-led Intervention to Extend the HIV Treatment Cascade for Cardiovascular Disease Prevention

Strategies to improve uptake of cardiovascular disease preventive therapies among people living with HIV (PLHIV) are urgently needed. This study tests an innovative prevention nurse intervention to extend the HIV/AIDS treatment cascade for the treatment of hypertension and hyperlipidemia among PLHIV on suppressive antiretroviral therapy. This intervention may be scalable …

diabetes
hyperlipidemia
antihypertensive drugs
AIDS
hypertension
  • 0 views
  • 25 Jan, 2021
  • 2 locations
Statins in Reducing Events in the Elderly (STAREE) Heart Sub-study

The STAREE-HEART sub-study will examine the effect of statin treatment over a 3-year period compared with placebo on markers of cardiac ageing. This will include determining global longitudinal strain with transthoracic echocardiography, atrial fibrillation with home measures twice daily for two weeks and changes in biomarkers.

electrocardiogram
fibrillation
hmg-coa reductase inhibitors
diagnostic procedure
12 lead ECG
  • 8 views
  • 26 Jan, 2021
  • 1 location